Research Associate (Antibody-Assisted Structure-Based Drug Discovery)
Vacancy ID: 1009
Department: Molecular & Cell Biology
Vacancy terms: Full-time fixed term contract until 31 December 2021 with the possibility of extension
Salary details: Grade 7 £34,189 to £39,609 per annum
Hours per week: 37.5
About the role
The University of Leicester, LifeArc and UCB Biopharma have established a research consortium to develop the innovative use of antibodies as powerful tools in structure-based drug discovery and design (SBD3). This will allow the identification of new opportunities for drug discovery, including novel regulatory or allosteric sites and protein conformational states, as well as providing a structural framework to guide the design of potential small molecule therapeutics. The Antibody-Assisted Structure-Based Drug Discovery Consortium is seeking to recruit a talented and highly motivated research scientist, with proven expertise in all aspects of NMR structural biology and its integration with X-ray crystallography, protein-ligand interaction studies and general biophysical characterisation of proteins. This is an exciting opportunity to join a team of 4 postdoctoral scientists based at Leicester and to make a major contribution to the development of an important new area of translational research, with the potential to revolutionise knowledge-based drug discovery. The research staff will be based in Prof Mark Carr’s structural biology research group at the University of Leicester, but there will be extensive interactions with research scientists at both LifeArc and UCB Biopharma.
The Leicester Institute of Structural and Chemical Biology is superbly equipped for all aspects of NMR and X-ray based structural biology, including 600 (x2) and 800 MHz Bruker NMR spectrometers with cryoprobes, a Rigaku X-ray diffraction system, multiple robotic systems for preparing crystal screens, excellent computer facilities and a range of AKTA FPLC protein chromatography systems. The Consortium projects will also have access to excellent research facilities within the LifeArc and UCB Biopharma laboratories, including world-leading antibody selection and production facilities.
Prior to taking up the position you must have submitted or obtained a PhD in a relevant research area, such as structural studies of proteins and/or protein-ligand complexes using NMR spectroscopy and/or X-ray crystallography. You must have significant experience in the expressin, purification and biophysical characterisations of recombinant proteins, ideally with experience of producing isotopically labelled proteins for NMR studies.
You must be an excellent communicator and team worker, able to supervise, manage and train less experienced members of the research groups such as PhD and MSc students and build relationships with the external partners at UCB Biopharma and LifeArc to discuss research progress and disseminate findings.
Leicester is a leading University committed to international excellence, world-changing research and high quality, inspirational teaching. We are strongly committed to inclusivity, promoting equality and celebrating diversity among our staff and students. You will develop your career in a supportive and collaborative academic environment in one of the world’s leading research-intensive universities; elite in the excellence of our research, yet distinctive for the genuine synergy between our research and teaching.
Informal enquiries are welcome and should made to Professor Mark Carr on +44 (0)116 229 7075 or firstname.lastname@example.org.
Advert closes midnight on: 30 Apr 2019