Postdoctoral fellowship in analyzing innate immune regulation with focus on inflammasome activation during infection and inflammation (2 years)

Postdoctoral fellowship in analyzing innate immune regulation with focus on inflammasome activation during infection and inflammation (2 years)

Research Group of Saskia Erttmann, Department of Molecular Biology, Umea University

Umea, Sweden

The Erttmann laboratory at the Department of Molecular Biology, Umeå University, Sweden is recruiting a research associate (postdoc) on a 2 year fellowship in molecular biology / immunology to pursue a project aiming at elucidating and characterizing the regulation of inflammasomes during infection and inflammation.

The department is the host of Molecular Infection Medicine Sweden (MIMS), a partnership of EMBL (http://www.mims.umu.se) and is affiliated to both the Faculty of Science and Technology and to the Faculty of Medicine. The department has a pronounced dynamic international profile with faculty, students and guest researchers from many different countries. Researchers work in modern laboratories with well-equipped common facilities to create a framework for a highly creative and interactive environment.

Research topic
“Insight into inflammatory diseases – understanding the molecular mechanisms during the onset and resolution of inflammation“
The ability to assemble inflammasomes during tissue damage or in response to pathogen entry plays a major role in wound healing and protection of higher organisms from infections. However, defects in inflammasome regulation is associated with susceptibility to microbial infections and onset and progression of inflammatory disorders. The Erttmann laboratory is interested in understanding the detailed mechanisms of inflammasome assembly and tight regulation of inflammasomes during infection and inflammation (Erttmann SF et al. Immunity (2016) 45: 106).

Responsibilities
Your role
The successful candidate will participate in projects identifying and characterizing new key molecules involved in the regulation of inflammasomes.
• Development and conduction of assays to evaluate new molecules in inflammasome regulation
• Generation of CRIPR/Cas9 knockout cells and shRNA knock-down cells of candidate proteins of interest
• Application of biochemical, molecular biological, and immunological techniques to study cell signalling pathways (protein-protein interactions, western blot, RT-qPCR, FACS, sorting, fluorescence microscopy, etc.)
• Implementation of murine models of infection and inflammation
• Participation and contribution to scientific group meetings and discussions with collaborators from the Laboratory for Molecular Infection Medicine Sweden (MIMS)
• Contribution to publication of research findings
• Participation in training and supervision of scientists and research students in the group

Selection criteria

Essential
- PhD in molecular biology, cell biology, infection biology, biochemistry or a related discipline and experience relevant for the project
- Excellent written and oral English communication skills
- Significant experience in mammalian cell culture, transfection and transduction
- Interest in protein biochemistry and cell signalling
- Ability to work as part of a team as well as independently
- Ability to deliver results to required standard and schedule and to organize and prioritize own work with minimal supervision

Desirable
- Practical experience in using animal models of infection and inflammation
- Experience in primary cell culture
- Experience in FACS
- Experience in cell sorting
- Experience in microscopy

Research environment
The research group is composed of an international team based at the Department of Molecular Biology at Umeå University, Sweden. The group has access to state-of-the-art equipment and techniques for cell culture work, infection biology and immunology. The Department of Molecular Biology offer an international, stimulating and collaborative research environment, in which your scientific career development is fostered.

Position summary
Full time position, two years (stipend) – start according to agreement

Application
The application should contain
1. Cover letter highlighting your research interest, qualification/experience and motivation (max. two A4 pages)
2. CV including publication list
3. Copy of PhD certificate
4. Contact information (including e-mail addresses) of 2-3 academic references
5. Other relevant documentation(s) you wish to include in support of your application

The application should be submitted as a single PDF file and sent to saskia.erttmann@umu.se

For questions, please contact:
Assistant Prof. Saskia Erttmann
Email: saskia.erttmann@umu.se
Dept. of Molecular Biology
Umeå University, Sweden
Welcome with your application!

About Umeå University:
Umeå University is dedicated to provide creative environments for learning and work. We offer a wide variety of courses and programs, world leading research, and excellent innovation and collaboration opportunities. More than 4 400 employees and 34 000 students have already chosen Umeå University.

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Position

Postdoctoral fellowship in analyzing innate immune regulation with focus on inflammasome activation during infection and inflammation (2 years)