Postdoctoral research about DNA helicases in cancer

Postdoctoral research about DNA helicases in cancer

Department of Medical Biochemistry and Biophysics, Umeå University

Umeå, Sweden

We are looking for a postdoctoral fellow to perform research within the field of Pif1 DNA helicases for a period of two years starting September 2019 or as agreed. The research will be conducted at the department of Medical Biochemistry and Biophysics. Last day of application is May 10th 2019.

Project description
The project will be conducted under the supervision of doctor Nasim Sabouri. The research in the group is focused on understanding the function of Pif1 helicases that are connected to familial breast cancer. One of the goals are to understand how Pif1 helicases promote genome integrity by using Schizosaccharomyces pombe as a model organism, and to understand why mutations in a highly evolutionary conserved region of Pif1 helicases are connected to breast cancer. Pif1 helicases promote replication fork progression at many hard-to-replicate regions in the genome. They are multi-tasking enzymes and have the ability to remove proteins from DNA, unwind G-quadruplex DNA structures, remove R-loops, and to perform DNA rewinding. The goal of this specific project is to achieve a deeper mechanistic insight into the different functions of Pif1 helicases.

Methods used in the project are biochemical methods, such as protein expression, protein purifications, helicase assays and EMSA.

Qualification requirements and other desirable requirements
In the first place, applicants who have completed a doctoral degree no more than three years before the application deadline are considered. If there are special reasons, an earlier doctoral degree could be considered. The candidates must hold a PhD in biochemistry, molecular biology, or similar, at the time of recruitment and have excellent verbal and written English communication skills.
We are looking for a highly talented and motivated candidate with a record of productive research, that function independently as well as part of a team. Previous research within the field of genome stability and helicases is highly desired. Furthermore, a strong background in biochemistry, and molecular biology is also highly desired, as well as previous experience with S. pombe.

Application
The application shall be send as one combined pdf document including the following documents:

- A short description of your research interests and why you are interested in this project (max one A4 page).
- A project description including a project proposal for how you would biochemically study Pif1 helicases to understand their role in genome integrity. The description should include an aim, introduction, methods, and work plan (max 2 A4 pages).
- Curriculum vitae (CV) and list of publications.
- Copies of diplomas and PhD thesis diploma.
- Contact information for two reference persons.

More information
For further information, please contact Nasim Sabouri: nasim.sabouri@umu.se.

The application, marked with reference number FS 2.1.6-626-19, must be sent to medel@diarie.umu.se (state the reference number as subject) or to Umeå University, Registrator, 901 87 Umeå, at the latest May 10 2019.

About us
The Department of Medical Biochemistry and Biophysics is located within the Chemical Biological Centre (in Swedish “Kemiskt Biologiskt Centrum”, KBC) – an interdisciplinary research centre for the natural sciences and medicine at Umeå University and the Swedish University of Agricultural Sciences. The centre is unique in its collaborative structure and offers an excellent scientific infrastructure with several core facilities and technical platforms. Our goal is to promote a positive, creative, and interdisciplinary environment for research combined with an excellent graduate and undergraduate education. You can find more information here: www.umu.se/en/kbc.

Umeå University is dedicated to providing creative environments for learning and work. We offer a wide variety of courses and programs, world leading research, and excellent innovation and collaboration opportunities. 4 000 employees and nearly 34 000 students have already chosen Umeå University.

We look forward to receive your application!

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Postdoctoral research about DNA helicases in cancer