Senior Biostatistician

Senior Biostatistician

Fundacio privada institut de salut global de Barcelona (ISGLOBAL)

Barcelona, Spain

Malaria remains a public health problem across the developing world. After achieving remarkable advances from 2000 to 2015, the global fight against malaria has stalled. The World Malaria Report 2018 estimates an increase to 219 million cases in 2017 compared to 216 million in 2016. We are currently not on track to achieve the goals proposed by WHO in the Global Technical Strategy for Malaria 2016-2030 (GTS).

Vector control, our most effective prevention strategy, is now doubly threatened by residual transmission and insecticide resistance. New tools are needed to control residual transmission, one of the key liabilities of vector control today.

Ivermectin is an endectocide, a drug with excellent safety profile that can kill ecto- and endo-parasites, as well as mosquitoes fed on treated humans or animals. Mass drug administration (MDA) of ivermectin to humans and/or livestock holds the potential to complement the malaria toolbox by tackling residual transmission and help overcoming insecticide resistance.

The project
BOHEMIA is a Unitaid funded, 4-year project that combines evidence generation and stakeholder engagement to create an enabling environment for ivermectin as a first-in-class endectocide for malaria prevention. This will be achieved by generating evidence to support a WHO policy recommendation, briefing and engagement of country and regional leaders and civil society in order to forge country ownership and create demand, as well as ensuring supply of quality product by enabling manufacturer engagement as suppliers of quality, high volume/low cost product sufficient for malaria indication.

Evidence generation will consist of two independently powered cluster-randomized clinical trials in Tanzania and Mozambique with analysis of impact on infection incidence, as well as supporting entomological outcomes.

The institution
ISGlobal – Barcelona Institute for Global Health is a research center in international health whose ultimate goal is to help close the gaps in health disparities between and within different regions of the world. For this, we engage in knowledge generation, translation and implementation. ISGlobal is a WHO Collaborative Center for Malaria Control, Elimination and Eradication.

ISGlobal is looking for an experienced Biostatistician for the BOHEMIA project.

Job title: Senior Biostatistician (SB)
Primary report: BOHEMIA Principal Investigator (PI)
Secondary report: Sergi Sanz (lead of statistics)
Based in: Barcelona

The SB will work across malaria projects in during the first year before focusing 100% on BOHEMIA until project end.

Essential duties and responsibilities

• Contributes to study design for project clinical trials and allied studies
• Contributes to data management including:
 Database design
 Data flow
 Data quality assurance
 Data cleaning as needed
• Generates the first draft of the analytical plan for every work package (epidemiology, entomology, safety, animal health, economics…) and incorporates input from the corresponding leaders.
• Creates analytical models to help reaching conclusions and making decisions based on the trial results
• Contributes to data visualization
• Contributes to manuscript drafting
• Proposes different uses for already collected databases
• Works with other malaria projects within ISGlobal to generate synergies and advance institutional goals
• Participates in internal malaria and/or biostatistics meetings
• Works towards assuring timely and appropriate data and safety monitoring of trials
• Contributes to epidemiological modelling and meta-analysis



• PhD in biostatistics
• Bachelor degree in mathematics, epidemiology, biological or medical sciences
• At least 5 years of experience with different types of clinical trials and across the clinical trial lifecycle, including study design, protocol development, data management and analysis
• Expert management of statistics software at efficient program level to assure reproducibility of data analysis.
• Experience with version control
• Experience with data management systems
• Excellent communications and collaboration skills, experience working in diverse cultures


• Previous experience in malaria
• Previous experience in prevention trials, including vector or vaccines
• Working experience in Spanish or Portuguese
• Experience with Stata, R, Java or Python
• Familiarity with Open Clinica, RedCap, and ODK

Additional skills

• Results-oriented approach to problem solving
• Accustomed to team work
• Ability to work independently where necessary

This position requires international travel, up to 4 weeks/year, including site visits to rural Tanzania and Mozambique

Please apply via recruiter’s website.