Postdoctoral Fellowships: Epigenetic mechanisms regulating energy balance

Postdoctoral Fellowships: Epigenetic mechanisms regulating energy balance

Baylor College of Medicine

Houston, TX, United States

In the Waterland laboratory our overarching goal is to understand how early environment affects epigenetic development, setting the stage for disease later in life. Multiple opportunities are currently available for highly motivated postdoctoral researchers to explore fundamental questions regarding the role of epigenetic mechanisms in brain development and energy balance. As part of an R01-funded project in collaboration with neuroanatomist Richard Simerly we are using mouse models to improve our understanding of how epigenetic and neuroanatomic development work together in the establishment of energy balance mechanisms in the hypothalamus. Toward this goal, we are developing novel approaches to probe cell-type specific epigenetic changes during hypothalamic development, combining techniques including microdissection, fluorescence-activated nuclear sorting, DNA methylation analysis by whole-genome bisulfite sequencing, and transcriptional profiling (bulk and single-cell RNA-seq). We link neuroepigenomic factors with metabolic outcomes including energy expenditure, physical activity, food intake, and body composition. Individuals with relevant backgrounds, including in neuroscience, epigenomics, genetics, cell biology, developmental biology, computer science, and nutrition are encouraged to apply. The successful candidate will work independently and take a leading role, under the guidance and supervision of the PI. The position is based in the Texas Medical Center. The world’s largest medical center and a vibrant and collaborative research environment, the TMC is located in Houston, TX, celebrated as the most diverse city in the US and for its low cost of living. Candidates must be recent recipients of a Ph.D. with good publications in a relevant discipline. US citizens and permanent residents are particularly encouraged to apply.  Applicants should submit (in a merged PDF) a statement of research interests, curriculum vitae, and names, telephone numbers, and email addresses of three referees to: Robert A. Waterland, Ph.D., Departments of Pediatrics and Molecular & Human Genetics, Baylor College of Medicine, 1100 Bates St., Houston, TX 77030; E-mail: waterland@bcm.edu. Baylor College of Medicine is an Equal Opportunity/ Affirmative Action/ Equal Access Employer.


For more information see: https://www.bcm.edu/research/labs/robert-waterland


Key words: bioinformatics, bisulfite-seq, computational biology, development, developmental origins, DNA methylation, DOHaD, exercise, epigenetics, epigenome, epigenomic, human, hypothalamus, glia, mammalian, mouse, neuron, neuroscience, next-generation sequencing, nutrition, obesity, postdoc, physical activity


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Postdoctoral Fellowships: Epigenetic mechanisms regulating energy balance