Postdoctoral Researcher in beta-cell regeneration in zebrafish

Postdoctoral Researcher in beta-cell regeneration in zebrafish

Karolinska Institutet (KI)

Stockholm, Sweden

Olov Anderssons research group, part of Department of Cell and Molecular Biology (CMB),  recently moved to Biomedicum. A new interdisciplinary research center designed to concentrate much of the experimental research conducted at Karolinska Institutet Campus Solna under one roof to promote collaboration. Biomedicum will house approximately 1,600 researchers and other personnel and allow expensive equipment to be shared and utilized more effectively.

Division and Duties
Olov Anderssons research group are seeking a highly motivated and enthusiastic postdoctoral fellow to study how small molecules can promote regeneration of beta-cells in zebrafish. In an ERC-funded lab the succesfull applicant will be using chemical-genetic screening techniques in zebrafish to identify compounds, genes and signalling pathways that can promote β-cell regeneration. For examples of how the research can be conducted, see:

Andersson et al., Cell Metabolism:
http://www.cell.com/cell-metabolism/abstract/S1550-4131(12)00188-X

Lu et al., The EMBO Journal:
http://emboj.embopress.org/content/early/2016/08/11/embj.201592903.long

Liu et al., Diabetes:
http://diabetes.diabetesjournals.org/content/early/2017/09/30/db16-1587

The present project will extend our initial studies using pharmacology to genetics in zebrafish, as well as to studies in the mouse. The studies will include assessing neogenesis/differentation and reprgramming to beta cells, and how such cellular changes affect glycemia.

The zebrafish are amenable to efficient transgenesis and high-resolution imaging. We will make use of these properties to generate transgenic/mutant zebrafish for single-cell analysis of phenotypes. The successful applicants will have a strong background in cell and molecular biology or biochemistry, and keen interest in beta-cell regeneration using model organisms.


Entry requirements
We are looking for independent and driven candidates who have at least one first-name publication in a peer-reviewed journal. A documented ability to independently carry out experimental research projects is required, as are good communication skills in spoken and written English.

The successful applicants may have experience in one or several of the following techniques/models:

  1. Molecular, cellular and biochemical techniques, e.g. cloning, Q-PCR, and immunohistochemistry
  2. Drug screening
  3. Bioinformatics
  4. Metabolism/diabetes research in mouse models
  5. Organoid cultures
  6. Zebrafish as a model system

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence.

Application process
An employment application must contain the following documents in English or Swedish:

  • A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • Cover letter stating the motivation to apply and key skills that match the profile (no more than one page)

The application is to be submitted through the Varbi recruitment system.

Karolinska Institutet is one of the world’s leading medical universities. Its vision is to significantly contribute to the improvement of human health. Karolinska Institutet accounts for the single largest share of all academic medical research conducted in Sweden and offers the country’s broadest range of education in medicine and health sciences. The Nobel Assembly at Karolinska Institutet selects the Nobel laureates in Physiology or Medicine.
Pursuant to the regulations of the Swedish National Archives, applications are kept on file for two years after the appointment has gained legal force. The regulations do not apply to attachments that have been printed or otherwise published.
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Quote Reference: 260142

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