Postdoctoral Research Scientist in Regulatory Pathways During Development

Department of Physiology, Anatomy and Genetics (DPAG), University of Oxford

Oxford, South East England, United Kingdom

Salary: Grade 7: Salary in the range £32,236 - £37,345 p.a

We are seeking to appoint a Postdoctoral Research Scientist to join the research group of Dr Sarah De Val at the University of Oxford. Our lab aims studies the different regulatory pathways which control gene expression within the vasculature, with an emphasis on transcriptional regulation of endothelial heterogeneity. This postdoctoral position is part of a recently awarded MRC project grant focused on understanding the role of NFAT transcription factors in the development of the vasculature. This builds on recent research in our laboratory delineating the regulatory pathways controlling arterio-venous and lymphatic identity, and is anticipated to involve Next-Gen sequencing, cell culture and both transgenic mouse and zebrafish models.

The successful applicant will be responsible for analyzing mutant mouse lines, and carrying out in vivo enhancer analysis in transgenic mice and zebrafish models (a zebrafish specialist will assist with the fish work). Additionally, you will perform and analyse ChIP-seq experiments on variety of cell lines, and conduct a variety of knock-down and over-expression studies in both in vitro and in vivo settings. You will be required to manage your own academic research and administrative activities, write up results for publication in international peer-reviewed journals and prepare scientific reports in order to represent the research group at external forums. You will also be responsible for reviewing and refining work hypotheses, developing ideas for generating research income, and contributing ideas for new research projects.

We require all applicants to hold, or be near completion of, a PhD/DPhil in a relevant field, and will have at least one first author publication or similar. You will have previous experience with mutant mouse models and also in the field of transcriptional regulation. You will also have extensive expertise in basic molecular biology techniques. You must either hold a personal license to work with animals in the UK or be prepared to obtain such a license via attendance of in-house courses. You will have the ability to clearly communicate research ideas in both written and oral presentation, and be able to assist members of the group or people working on collaborative projects to become familiar with new methodologies and to act as a source of information.

Although a member of the Department of Physiology, Anatomy & Genetics, you will initially be based within the Ludwig Institute for Cancer Research, in the Old Road Campus Research Building, Headington Campus, Oxford, OX3 7DQ.

The position is funded by a project grant from the MRC until 31 March 2022.

The closing date for applications is 12.00 noon on Friday 26 April 2019. Interviews are likely to be held the week beginning Monday 6 May 2019.

Please apply via recruiter’s website.

Quote Reference: University of Oxford-itox_ac-140039