Director, Pre-clinical Informatics

Director, Pre-clinical Informatics

National Center for Advancing Sciences, National Institutes of Health

Rockville, MD, United States

The National Center for Advancing Translational Sciences (NCATS), a major research component of the National Institutes of Health (NIH) and the Department of Health and Human Services is seeking applications from exceptional informatics scientists to serve as the lead for Informatics for the Division of Pre-Clinical Innovation (DPI). DPI studies translation of basic discoveries into tangible improvements to human health at a systems level as a scientific and operational problem. The scientists within DPI come from a broad range of scientific disciplines – including, among others, therapeutic discovery, preclinical development, toxicology, biomarkers and clinical application – to reduce, remove, or bypass significant bottlenecks across the entire continuum of translation and to train the future translational science workforce.


The incumbent sets the informatics research agenda, leading a diverse team of data science, bioinformatics, cheminformatics, and software development professionals with discovery, preclinical development and clinical repurposing expertise to advance NCATS translational science initiatives. The position requires a strong interdisciplinary foundation in therapeutic development, genomics, mathematics, and algorithm and informatics platform development. The leader should have a strong record of high-impact publications and experience providing tools and resources to the broader research community. The scientist in this position will serve as leader in this role and will interface with project team leads to ensure proper direction, planning, execution and completion of projects. The incumbent will be a point person responsible for guiding and advancing collaborative projects through milestone driven practices and procedures

The ideal candidate will possess a doctoral degree (MD, PhD or equivalent) with biomedical research or informatics training and be an internationally-recognized and accomplished researcher in data science, clinical informatics, bioinformatics, computational chemistry or cheminformatics. S/he will be familiar with all aspects of preclinical translation, with a particular interest and accomplishment in novel technology and paradigm development. The candidate must have expertise in multiple aspects of preclinical translation from target validation through early development of therapeutics and/or diagnostics to proof-of-concept in humans. S/he will have a broad and first-hand knowledge of the field of rare disease therapeutic development, including small molecule, biologic, and gene-therapy approaches. Demonstrated collaborative leadership experience working with scientifically diverse research programs, administrative staff, patient advocacy groups, and government/nonprofit organizations is ideal. Open to both U.S. citizens and non-U.S. citizens.  


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Director, Pre-clinical Informatics