Our team is investigating how B cells influence disease in the context of autoimmunity and infection, with an emphasis on their cytokine-mediated functions. We previously found that B cells could regulate immunity through the provision of IL-10 and IL-35 (Nature Immunology 2002, Immunity 2010, Nature 2014, Immunity 2018), and established that the major B cell subsets producing these cytokines in vivowere two distinct subsets of antibody-secreting cells (Immunity 2010, Nature 2014, Immunity 2018). We have also established that B cells contributed to the pathogenesis of autoimmune disease through the production of IL-6 (J Exp Med 2012).
The project will address the molecular mechanisms controlling the expression of pro- versus anti-inflammatory cytokines in B cells using novel cytokine reporter mouse models, state of the art genetic approaches, and pharmacological compounds identified via a screening approach that boost IL-10 production in human B cells. The project will therefore also involve the characterization of cytokine-producing human B cells. One long-term goal of the project is to develop a B cell-based therapy for auto-immune disease.
The Institut Necker Enfants Malades (INEM) with its two departments in immunology and cellular biology, and its intimate partnerships with the IMAGINE institute as well as the Necker Enfants-Malades Hospital, offers an excellent environment to conduct these studies. The laboratory “Immunity in Health and Disease” is within the Necker-Enfants Malades Hospital at the interface between fundamental and clinical research.
The project is funded by a European Research Council (ERC) grant. The candidate should have a strong track record in the field of cellular immunology, or molecular biology. Expertise in experimental models of autoimmunity and/or human immunology is highly welcome.
The position is open.Salary will be according to experience following INSERM regulation.
INEM- Team 16 – Immunity in Health and Disease
14 Rue Maria Helena Vieira da Silva
75993 Paris Cedex 14
Selected publications from the team:
Lino AC. et al. Immunity. 2018. vol. 49 p120-133.
Kieback et al. Immunity. 2016. vol. 44 p1114-1126.
Shen et al. Nature Reviews Immunology. 2015. vol. 15 p441-451.
Shen P. et al. Nature. 2014. vol. 507 p366-370.
Neves P. et al. Immunity. 2010. vol. 33 p777-790.
Fillatreau S. et al. Nature Reviews Immunology. 2008. vol. 8 p391-397.
Fillatreau S. et al. Nature Immunology. 2002. vol. 3 p944-950