Postdoctoral Position in the Translational Allergic Immunopathology Unit – NIAID/NIH
The Division of Intramural Research is seeking a postdoctoral applicant to work within the Translational Allergic Immunopathology Unit of the Laboratory of Allergic Diseases in the National Institute of Allergy and Infectious Diseases, National Institutes of Health.
We are seeking two highly devoted and enthusiastic Ph.D. or M.D./Ph.D. scientists to join our group as postdoctoral research fellows. We recently identified the genetic basis for elevated basal serum tryptase and linked this finding to mast cell reactivity and eosinophilic inflammation. Our laboratory focuses on the immunogenetics of allergic myeloid cell (i.e., mast cell, eosinophil, and basophil) reactivity and how inborn and acquired genetic mutations lead to intrinsic reactivity and increased proliferation that results in severe allergic reactions or symptoms, at times even in the absence of an antigenic trigger.
We have two postdoctoral positions open to support these efforts. These positions will use primary human cellular assays as well as mouse models of human myeloid allergic diseases. The research fellows will be expected to employ a number of immunogenetic and molecular techniques both in vitro and in vivo to refine our understanding of the diseases we have recently identified, characterize new disorders, and devise novel therapies to prevent severe allergic immunopathology and reactions caused by myeloid cells in humans.
The ideal candidates will have experience in basic immunological methods including the use of mouse models and in vitro cell culture, flow cytometric purification of cell populations, substantial expertise with human/murine immune cell functional assays (including high definition polychromatic phospho-flow cytometry, as well as mast cell purification, differentiation, and degranulation), gene editing via CRISPR/Cas9, cell transfection/transduction, western blotting, gene expression assays, and Sanger and next gen sequencing.
• Ph.D. and/or M.D. in immunology or genetics
• Scientific knowledge and research experience in the cellular and molecular aspects of basic immunology with a track record of publication in peer-reviewed journals
• Able to work well in a highly dynamic, collaborative work environment
Interested individuals should send a cover letter describing career plans, updated curriculum vitae with research statement, and the names/contact information for three professional references to
Jonathan Lyons, M.D.
Chief, Translational Allergic Immunopathology Unit
Laboratory of Allergic Diseases, NIAID, NIH
10 Clinical Center Drive
Building 10, Room 11N240
Bethesda, Maryland 20892
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