Postdoctoral Position in the Challen Lab

Postdoctoral Position in the Challen Lab

Washington University School of Medicine (WUSM), WUSTL

St. Louis, MO, United States

There is an opportunity for research in the laboratory of Dr. Grant Challen, which studies how genetic mutations influence the function of blood-forming stem cells in the bone marrow (hematopoietic stem cells = ‘”HSCs”) and contribute to the development of blood cancers such as myelodysplastic syndromes (= “MDS”), myeloproliferative neoplasms (= “MPN”), acute myeloid leukemia (= “AML”) and T-cell acute lymphoblastic leukemia (= “T-ALL”). The Challen lab using cutting-edge techniques such as next-generation sequencing, CRISPR/Cas9 and high-throughput flow cytometry to investigate these processes in model systems incorporating cancer cell lines, transgenic mouse models, and primary cells from human patients. The overall goal of the lab is to understand how different processes contribute to turning a normal stem cell into cancer, with the aim of identifying new treatment approaches for patients with blood cancers.

The successful candidate will have the opportunity to work on any number of projects investigating how epigenetic modifications influence HSC fate decisions, and how genetic mutations in epigenetic regulators contribute to clonal expansion of mutant HSCs in clonal hematopoiesis, and predispose for transformation to hematopoietic malignancies.

The post-doctoral scholar will be responsible for managing their own projects (under the mentorship of Dr. Challen) as well as contributing to ongoing projects with other trainees. Must have troubleshooting skills, independent analytical thinking and research planning skills as well as demonstrated ability to work independently and communicate with the laboratory staff and investigators. Experience in flow cytometry and small animal handling is desirable, but not essential. Willingness to learn these techniques is preferred.

For more information about our lab research please visit our website ( and follow us on Twitter (challenlab). Qualified candidates can contact Dr. Grant Challen ( with CV and research statement attached.

Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status….


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Postdoctoral Position in the Challen Lab