3 Year Postdoc (Bioinformatics and Single Cell Biology)

3 Year Postdoc (Bioinformatics and Single Cell Biology)

University of Cambridge

Cambridge, East Midlands, United Kingdom

Bioinformatics and Single Cell Genomics


Applications are invited for a position in the Epithelial Tumour Biology group at the University of Cambridge which focuses on studying and identifying the earliest cellular changes leading to breast and lung cancer (Khaled W.T. 2015 Nat Commun, Bach K. et al. Nat Commun 2017 & Lazarus K. et al. Nat Commun 2018). In this project we will be working in collaboration with Dr. John Marioni (EBI, CRUK, CI) to build a comprehensive breast cell atlas. We will be using scRNAseq, scATACseq and CRISPR-scaring to chart the cellular changes in the breast under different healthy conditions. These tools will allow us to understand the impact of age and parity, known breast cancer risk factors, on cell fate and tissue homeostasis.


Applicants should have a strong interest in developmental biology, cancer biology and are expected to hold or obtain shortly, a PhD in the life sciences. They must have demonstrable experience in one or more of the following areas:

  • Analysing NGS data (using Unix, R, Python, etc.)
  • Studying genetically engineered mouse models (ideally breast or lung cancer models)
  • Tumour immunology
  • Cell biology


The successful applicant will be a careful and methodical worker, accurate and ready to take responsibility as part of a team. They will be self-motivated and able to organise, perform and analyse experiments with minimal instruction. Ideally, they will have relevant experience and be able to work efficiently and productively without direct supervision. Careful observation and accurate computer-based record-keeping and presentation are essential.


Successful candidates who have not been awarded their PhD by the appointment date will be appointed as a Research Assistant at Grade 5 (£26,243-£30,395). Upon the award of the PhD the individual will be promoted to Research Associate, Grade 7 (£32,236-£39,609). The closing date is 26th April 2019.


Interviews will be carried out as applications are received so please apply early. Informal enquiries are encouraged and should be made to Dr. Walid T. Khaled (wtk22@cam.ac.uk).


The position is available for 3 years (subject to a probation period) in the first instance and is available from 1st May 2019 or soon thereafter. There is flexibility in the start date for the appropriate candidate.


To apply online for this vacancy, please go to http://www.jobs.cam.ac.uk/job/20633/. This will route you to the University’s Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.Applications from agencies will not be considered.


For the online application, you will need to provide your personal details, names and e-mail addresses of two referees familiar with your recent research, CV, publications and a cover letter (including a description of your experience as it relates to the job specifications). For enquiries about the online application process please contact Ms. Saez (pharsect@hermes.cam.ac.uk).


Please quote reference PL18346 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Please apply via recruiter’s website.

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