Research Assistant in Phenotypic Screening Using Parkinson's Disease Models

Nuffield Department of Clinical Neurosciences, University of Oxford

Oxford, South East England, United Kingdom

Salary: Grade 6: £28,660 - £34,189 p.a.


We are seeking a highly motivated research scientist to support an ongoing program of research that aims to develop cell-based phenotypic assays and perform high throughput screening of pharmacological and genetic modifiers in iPSC-based models of neurodegeneration. The post is based at the Nuffield Department of Clinical Neurosciences at the University of Oxford and involves a collaboration with the Target Discovery Institute, the Oxford Drug Discovery Institute and FORMA Therapeutics.

The successful candidate will have prior research experience in primary cell culture and high-content imaging to work in a project that involves the development of phenotypic assays using iPSC-based and/or primary neuronal models. The postholder will join a small, dynamic team with a focus in the study of proteostasis pathways (specifically, ubiquitin signaling, mitochondrial dysfunction and endosomal trafficking) using cell lines and iPSC-based models of neurodegeneration.

Applicants should hold an MSc or equivalent degree and have strong research background in (a) confocal imaging and high content imaging screens (b) primary cell culture, ideally of iPSC-derived neurons and (c) understanding molecular mechanisms of neurodegeneration.

Informal enquiries are encouraged and should be addressed to Dr George Tofaris (

The post is full-time for a fixed-term until the 31 March 2020 in the first instance.

Only applications received before 12.00 midday on 8 April 2019 will be considered. Interviews will be held as soon as possible thereafter.

Please apply via recruiter’s website.

Quote Reference: University of Oxford-itox_ac-139882