Area of research:
PhD Student (m/f/d) in the field of translational biomedicine
A member of the Helmholtz Association of German Research Centers, the HZDR employs about 1,100 people. The Center's focus is on interdisciplinary research in the areas energy, health, and matter.
At the Institute of Radiooncology – OncoRay scientists specializing in medicine, physics, biology and IT work together to crucially improve the treatment of cancer by administering radiation therapy that is biologically personilized and technically optimizied.
As part of the Institute, the Department of Radiobiology, invites applications as PhD Student (m/f/d) in the field of translational biomedicine.
The position will be available as soon as possible and is embedded in a joint project between two groups with a strong experience in radiation biology and radiation oncology. The employment contract is limited to three years. The weekly working time will be total 50% of the regular weekly working time according to the collective agreement TVöD.
Tasks:We invite applications for a PhD Student (m/f/d) highly motivated to work in the field of translational bio-medicine to identify cancer-specific metabolic pathways that can be employed as new biomarkers for radiotherapy and potential targets for tumor radiosensitization.Our groups are working on identifying tumor biomarkers for radiation oncology which can be used to aid cancer prognosis and treatment. Biomarkers that are deregulated in cancer stem cells (CSC) are of special interest because they may be used to predict treatment outcome and serve as potential targets for cancer therapy. This PhD project aims:to validate the role of distinct metabolic pathways in radioresistance and tumorigenic capacity of prostate cancer cellsto develop new experimental radiosensitizing therapy for the most essential metabolic regulatorsto analyze the impact of the distinct metabolic signatures on response of cancer patients to radiotherapyThis project will employ different in vitro models including established radioresistant cell lines, primary cell cultures as well as tumor xenograft models and tissue microarray analysis.
Requirements:strong interest in tumor biology and translational radiooncologyvery good university degree (Master/Diploma) in biology, biochemistry, biotechnology, molecular medicine or related fieldsexperience in molecular and cell biology techniqueshigh motivation to work in ambitious, multi-disciplinary and international research groupability to work independently, as part of a team and in collaboration with othersstrong problem-solving skills and creative thinkingexperience in working with laboratory animals (mice) is desirable but not essentialfluency in spoken and written English
We offer:interesting and motivating workplacearranging for flexible working hours to find a balance between work and family lifeparticipating in job-oriented educational courses