TRIM-NET, a training network in drug discovery targeting TRIM ubiquitin ligases is recruiting 12 PhD students – H2020-MSCA-ITN-2018 (GA 813599).
The Tripartite motif (TRIM) family of Ubiquitin E3 ligases plays an important role in many physiological processes and in many diseases including cancer, neurodegenerative and neuro-muscular disorders and rare genetic diseases. TRIM-NET is a training programme for Early-Stage Researchers that will integrate complementary expertise and multidisciplinary approaches to exploit common targeting strategies for translational applications. The consortium will train a cohort of young researchers in skills and expertise essential for biomedical research focusing on: i) determining how TRIM proteins contribute to disease; ii) developing strategies to modulate TRIM protein activity; iii) designing high throughput screening assays for drug discovery. The project consists of 12 individual research projects (see www.trimnet.eu and below). As the scientific work packages are highly integrated, recruited students will avail of techniques and training opportunities, including secondments, across the work packages.
Overview of the 12 vacant ESR positions
ESR1 – Regulation of α-synuclein expression by TRIM17 and TRIM41 in Parkinson’s Disease – Solange Desagher CNRS-IGMM, Montpellier, France
ESR2 – Autophagic defects in Lafora disease due to mutations in the TRIM-like E3 ligase Malin – Pascual Sanz CSIC, Valencia, Spain
ESR3 – Function of TRIM32, the ubiquitin ligase mutated in Limb Girdle Muscular Dystrophy 2H – Germana Meroni DSV, University of Trieste, Trieste, Italy
ESR4 – Developing new strategies to limit TRIM63/MuRF1-mediated muscle protein loss – Daniel Taillandier INRA, Clermont Ferrand, France
ESR5 – Determining the role of TRIM25 in Androgen Receptor-dependent Cancers - Christine Blattner KIT, Karlsruhe, Germany
ESR6 – Defining the role of TRIM33 in hormone-dependent breast cancer – Wilbert Zwart, NKI-AVL, Amsterdam, The Nederlands
ESR7 – Determining the role TRIM28 in hormone-dependent prostate cancer – Wilbert Zwart, NKI-AVL, Amsterdam, The Nederland
ESR8 – Dissecting TRIM8 function in the pathogenesis of glioblastoma – Giuseppe Merla, CSS-IRCCS, San Giovanni Rotondo, Italy
ESR9 – Understanding the role of Arsenic in modulating PML/TRIM19 activity – Ronald T. Hay, University of Dundee, Dundee, UK
ESR10 – Study of the TRIM-E2 interaction specific determinants and identification of TRIM-associated DUBs – Germana Meroni
DSV, University of Trieste, Trieste, Italy
ESR11- Development of TRIM-specific assays suitable for High-Throughput-Screening – Huib Ovaa, LUMC, Leiden, The Nederlands
ESR12 – Design of small compounds to modulate TRIM-substrate interactions – Huib Ovaa, LUMC, Leiden, The Nederlands
Eligibility and Requirements
• Not having a doctoral degree yet
• Less than 4 years full-time research experience
• A degree which entitles to embark on a doctorate in the host countries
• Less than 12 months spent in the host country in the 3 years prior to the recruitment
Job offer and Benefits
• Attractive salary
• 3-year full-time employment contract in accordance with the Marie Skłodowska-Curie Action regulations for Early Stage Researchers;
• Enrollment in a PhD programme at the local partner’s institution.
Applications should include:
• A cover letter indicating the top three projects of election in the order of preference and the indication of the countries of residence during the last 3 years;
• CV (contact details, education, work experience, list of publications, prizes/awards, language skills, etc….);
• A motivation letter;
• A digital copy of the degree certificate and official academic transcripts of Bsc and Msc studies (Master diploma/certificate or equivalent qualification giving access to the Doctoral Programme + Transcript of Records including examinations and scores obtained. If the documents are issued in a language other than English, a translation must be included, along with the original document);
• A documentation of English language qualifications;
• Two recommendation letters sent directly by the referees to email@example.com with the subject: “Letter concerning – Surname Name” and full contact details of the reference persons;
Application in a single pdf file should be sent by e-mail to firstname.lastname@example.org with indication of “TRIM-NET application” in the subject line. Equal consideration will be given to female and male applicants.
• Deadline for Application: April 15, 2019.
• The merit-based recruitment process will be on a competitive basis across all applicants for each project.
• Short-listed students will be interviewed via Skype on May 9-10, 2019.
• Students are expected to initiate their contracts between June 1st, 2019 and November 1st, 2019 depending on the PhD enrollment rules of the different countries.