Post-Doctoral Fellow

Post-Doctoral Fellow

Georgetown Lombardi Comprehensive Cancer Center

Washington, DC, United States


Post-doctoral fellows


University’s Lombardi Comprehensive Cancer Center is currently recruiting
talented scientists for post-doctoral fellowships in immuno-oncology in the
laboratory of Dr. Samir N. Khleif. 
The major focus
of the lab is the basic and translational research that is dedicated to
understanding the cellular/molecular mechanisms underlying immune cell
activation, localization and immunosuppression within the tumor
microenvironment. Another major focus of the lab is to decipher the mechanisms
leading to resistance to cancer immunotherapy.  Candidates with an extensive background in
tumor immunology, cellular and molecular immunology, and working with primary
human tumor specimens and mouse models of cancer are preferred. Successful post-doctoral
research would be expected to result in high profile publication and
presentation opportunities and help fulfill Georgetown’s mission to develop
cutting-edge cancer treatments of tomorrow.

description and expectations: Candidates should have a Ph.D. in Immunology or a
closely related field. The duties of this position will involve utilizing in
vivo mouse tumor models to understand mechanisms of immunotherapy resistance.  Experience in animal handling, drug
administration, and ex vivo analyses related to immune endpoints such as
complex multispectral flow cytometry, ELISPOT, cytometric bead array, TCR
immune-sequencing, and cell-based bioassays is highly desired.  The ideal candidate will also have in-depth
and hands-on expertise in analysis of human primary tumors, preferably with
experience in tumor dissociation, flow cytometry and single cell RNA sequencing.  Familiarity with handling large data sets to
investigate human immune pathways deregulated in cancer and
immunotherapy-resistant tumors is preferred. The candidate must be
proficient in
oral and written English, and able to work independently
and collaboratively in a matrixed environment to design, execute, interpret and
communicate immunotherapy studies.

About the Lab: The Khleif Laboratory offers a highly competitive, stimulating and
dynamic working environment within an exceptional scientific setting in an
international, young, enthusiastic, motivated team. The laboratory is working
on high-impact projects and conducts research that can be translated into the
clinical practice. The laboratory is part of the Lombardi Comprehensive Cancer
Center (LCCC), a multidisciplinary research center focusing on cancer,
genetics, metabolism and immune-therapy. LCCC offers many Core facilities
including: Imaging, Molecular Biology, Metabolomics, Histology and mouse
facility, etc. Technical support is granted within the lab. Georgetown
University Medical School is an equal opportunity employer and all eligible
candidates irrespective of their social background are welcome to apply.

Lab website:



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Post-Doctoral Fellow