postdoctoral fellowship

postdoctoral fellowship

Mass Eye & Ear Infirmary/Harvard Medical School

Boston, MA, United States

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NIH funded postdoctoral positions are
available in the laboratory of Dr. Zheng-Yi Chen of Harvard Medical School/Massachusetts
Eye & Ear Infirmary on the development and application of
CRISPR/Cas9-mediated gene editing to treat genetic deafness.

 

We are interested in developing
CRISPR/Cas9-mediated genome into new gene therapy paradigm for genetic hearing
loss from animal models to human patients. We are the first to show CRISPR
editing agents (Cas9 protein and sgRNAs in the form of RNP, ribonucleotide proteins) can be efficiently delivered into
mammalian hair cells resulting in high efficiency editing (Nat Biotech. Zuris et al
2014).
We have demonstrated that RNP delivery of editing agents rescued hearing in a
mouse model of human dominant deafness (Nature, Gao et al., 2018). Our main
focus is to develop genome editing therapy for hearing loss with particular interests
in the following areas: 1). Development of editing technology to improve
editing efficiency and specificity in vivo; 2). Developing new delivery
vehicles including nanoparticle based liposomes for RNP delivery of editing
machinery to target diverse somatic cells; 3). Detection of editing events in
situ; 4). Bioengineering of endonucleases to improve activity; 5). Advance
CRISPR to correct disease phenotype using iPS cells from human patients; 6).
Achieve efficient and accurate editing in large animal models including pig and
7). Develop new editing tools to target different mutations in the same
deafness gene.

 

The positions offer unique and exciting
opportunities to engaging in developing cutting-edge CRISPR technology for
inner ear application with direct implication in humans. The fellows will have
the opportunity to conduct the development of CRISPR technology for hearing
rescue in animal models in Boston and conduct pig model study in China. The
project involves collaboration with Dr. Qiaobing Xu of Tufts University and Dr.
David Liu of Broad Institute. We provide an interdisciplinary and collaborative
environment in all aspects of hearing research. A successful candidate (Ph.D,
M.D/Ph.D or MD) should have a strong background in genome editing technology,
genetics, molecular biology and strong interest in application of editing
technology to treat human diseases.

 

Please email a curriculum vita, a description
of research accomplishments and names of three references to:

 

Zheng-Yi Chen, D.Phil. (617-909-6090)             

Associate Professor                                               

Harvard Medical School                                        

Massachusetts Eye & Ear Infirmary                    

Zheng-Yi_Chen@meei.harvard.edu

 


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postdoctoral fellowship