Biology Group Leader, Trans-NIH RNAi Facility

Biology Group Leader, Trans-NIH RNAi Facility

Biology Group Leader, Trans-NIH RNAi Facility

Rockville, MD, United States

NCATS
seeks applications from outstanding candidates to direct the Trans-NIH RNAi
Facility, part of the Center’s intramural research program within the Division of
Pre-Clinical Innovation
. DPI researchers study translation of basic
discoveries into tangible improvements to human health at a systems level as a
scientific and operational problem. The scientists within the Division come
from a broad range of scientific disciplines, including therapeutic discovery, preclinical
development, toxicology, biomarkers and clinical application. Research
conducted in the DPI is designed to reduce, remove or bypass significant
bottlenecks across the entire continuum of translation and provide the
resources to train, cultivate and sustain future leaders of the biomedical
research workforce.

 

The
Leader will direct the laboratory operation of the Trans-NIH RNAi Facility (with
further informatics, automation, compound management, and project management
support) in collaboration with NIH intramural investigators to conduct
genome-wide RNAi screening projects – including assay development, screening
and validation – to understand functional biology and accelerate target
discovery and validation. In addition, he or she will be expected to develop
methods that advance the science of RNAi screening, and to perform education
and outreach to increase awareness of the RNAi program tools and methods. The Leader
also will be expected to pursue new technologies for exploring gene function,
including but not limited to CRISPR/Cas9 and related gene-editing approaches, as
well as to interrogation of biological systems with annotated sets of
perturbagens to advance the scientific breadth of the Facility.

 

The
ideal candidate must hold a doctoral degree (M.D., Ph.D. or equivalent) in a
relevant field and be a recognized expert and accomplished leader in the field.
He or she must have proven experience in the development of functional genomics
and high-throughput cell-based assay systems. The incumbent should be committed
to fostering diversity and inclusion in the workplace. He or she also must have
a documented track record of successfully managing a complex biomedical
research operation and monitoring operations in matters related to personnel,
budget, contracts, interagency agreements, and research grant writing and
monitoring – including tracking requests for supplements, extensions and other
related administrative issues. Experience in the screening of druggable
compound libraries, and validation of gene expression profiling utilizing quantitative
real-time PCR (qPCR), RNA sequencing, and related technologies is desirable. The
ideal candidate will be highly innovative, interactive and collaborative, and
will serve as a spokesperson for the Facility at NIH and at national and
international meetings and conferences.

 

The
current salary range is commensurate with experience and accomplishments; a
full civil service package of benefits (including retirement, health, life and
long-term care insurance, Thrift Savings Plan participation, etc.) is available.

 

Please
submit a cover letter describing your interest in the position, including a
career synopsis that demonstrates commitment to diversity and inclusion in the
workplace (1-3 pages); statement of research interests (1-2 pages); a current
curriculum vitae and complete bibliography; and the names and contact
information of three references to NCATSRnairecruitment@mail.nih.gov.
Application packages will only be accepted electronically. The position will
remain open until filled.

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Biology Group Leader, Trans-NIH RNAi Facility