Postdoctoral Research Scientist
Regulation of Anti-Tumour Immune Priming
Dr Ed Roberts
Starting Salary from £31,604 to £41,929 (Depending on experience) plus relocation allowance where appropriate. Initial 3 year fixed term contract.
Would you like to develop your scientific career in a research institute that is founded on the quality of its people, acknowledged for its collaborative environment and designed to promote the development of the most outstanding and dedicated scientists? Many early career researchers have already made that decision and at present over 100 of them are now benefiting from our excellent training programme.
The Cancer Research UK Beatson Institute supports cutting edge research into the molecular mechanisms of cancer development and is one of the leading research institutes in Europe. The Institute provides an outstanding research environment, underpinned by state-of-the-art core services and advanced technologies, with special emphasis on imaging, metabolomics, and in vivo models.
Our innovative and ambitious research themes focus on understanding the regulation of the tumour microenvironment and cancer metabolism, in particular:
• Intrinsic cancer cell vulnerabilities caused by cell growth
• Interplay between the tumour microenvironment, metastasis and recurrence
• Biology of early disease, aimed at developing a ‘Precision Prevention’ approach
We are building a new group focussed on understanding how anti-tumour immune responses are initiated in the lymph node (LN). We are interested in how the LN microenvironment is informed by signals from the periphery and how this influences downstream T cell outcomes. T cells stimulated within the tumour draining LN differentiate in a suboptimal manner and we seek to understand why and whether this can be manipulated to improve the quality and/or quantity of anti-tumour immunity. One major focus of our group is dendritic cells (DC) since these are incompletely activated in the tumour draining LN and these have the capacity to differentially skew anti-tumour T cells. Using in vivo models of both infection and cancer we seek to understand the channels of communication between the peripheral tissue and the lymph node to better understand how these can be manipulated to improve anti-tumour immunity. Ultimately we hope to investigate whether these interventions may synergise with existing immunotherapeutic approaches.
Applicants must have a PhD in a relevant field and be driven by scientific curiosity. Existing skills with regard to mammalian cell culture and flow cytometry along with experience of immunology and in vivo cancer models will be an advantage.
To find out more about this unique opportunity to establish advanced skills and expertise in the exciting field of tumour immunology please contact Dr. Ed Roberts, email firstname.lastname@example.org
At the Cancer Research UK Beatson Institute, we are committed to increasing the number of female scientists at this level and strongly encourage female applicants to apply. We have recently introduced a highly attractive, innovative maternity policy, which includes providing a postdoc with support and funding so that their projects can continue during their maternity leave.
All applications must be made via our website at http://www.beatson.gla.ac.uk/careers/postdoctoral-fellows/.
Closing date for applications: 03 May 2019