The major interest of Su lab is to understand how cumulative exposures to the environment over the lifetime of an individual impact response to new antigenic challenge at a later time point. We have shown that humans have memory phenotype T cells to pathogens to which they have never been exposed and this likely results from cross-reactive exposures to common microbes in the environment. We are interested in understanding how this type of memory response contributes to T cell immunity against new and emerging pathogens. We have an ongoing NIH R01 funded project to study this question using yellow fever vaccine as a system to perturb the human T cell repertoire. The study involves molecular approaches to capture specific T cell populations and deep profiling of vaccine-specific T cells. We will also follow up on the findings of our recent Science Immunology paper to understand how TCR cross-reactivity impacts the breath of antibody responses.
For more information, please see the following link: https://www.med.upenn.edu/apps/faculty/index.php/g275/p8679711
We are looking for someone who is scientific rigorous, collaborative, and have a background in immunology and/or single cell analyses.
If you are interested, please send your curriculum vitae and a cover letter with a statement of research and technical experience by e-mail to Dr. Laura Su at email@example.com