Postdoctoral Fellowship in cross-reactive T cell memory

Postdoctoral Fellowship in cross-reactive T cell memory

University of Pennsylvania

Philadelphia, PA, United States

The major interest of Su lab is to understand how cumulative exposures to the environment over the lifetime of an individual impact response to new antigenic challenge at a later time point. We have shown that humans have memory phenotype T cells to pathogens to which they have never been exposed and this likely results from cross-reactive exposures to common microbes in the environment. We are interested in understanding how this type of memory response contributes to T cell immunity against new and emerging pathogens. We have an ongoing NIH R01 funded project to study this question using yellow fever vaccine as a system to perturb the human T cell repertoire. The study involves molecular approaches to capture specific T cell populations and deep profiling of vaccine-specific T cells. We will also follow up on the findings of our recent Science Immunology paper to understand how TCR cross-reactivity impacts the breath of antibody responses.

For more information, please see the following link: https://www.med.upenn.edu/apps/faculty/index.php/g275/p8679711

We are looking for someone who is scientific rigorous, collaborative, and have a background in immunology and/or single cell analyses.

If you are interested, please send your curriculum vitae and a cover letter with a statement of research and technical experience by e-mail to Dr. Laura Su at laurasu@upenn.edu

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Postdoctoral Fellowship in cross-reactive T cell memory