Postdoctoral fellowship / research fellow

Postdoctoral fellowship / research fellow

Cryo-ET cell biology postdoctoral fellowship

Singapore, Singapore

A new postdoc position is available in my lab, located in the Centre for BioImaging Sciences, Department of Biological Sciences at the National University of Singapore, Singapore.

The candidate will investigate how eukaryotic cells control their chromatin structure at the level of nucleosomes and other nuclear complexes. Because this work will be done in situ, the candidate will use state-of-the-art technologies including – but not limited to – cryosectioning, cryo-FIB, electron cryotomography, 3-D classification, and subtomogram averaging. Examples can be found in our recent work:

www.molbiolcell.org/doi/10.1091/mbc.E18-05-0331

www.pnas.org/content/115/43/10977

jcb.rupress.org/content/early/2018/11/30/jcb.201809088

The Centre of BioImaging Sciences is equipped with state-of-the art instrumentation, including a Titan Krios cryo-TEM with a Falcon II direct-detection camera, a T12 cryo-TEM, a Vitrobot plunge freezer, a high-pressure freezer, a UC7/FC7 cryomicrotome, and a Helios FIB-SEM. The facility is actively undergoing upgrades. Core proteomics, computing, light microscopy, and cell-culture facilities are also available. Training in the theory and operation of key equipment and software is provided by dedicated staff.

Access to other equipment, such as a K2/K3 camera, energy filter, and light cryomicroscopes is available through our established collaborations or through local and international cryo-EM facilities. The candidate will also interact with long-term collaborators who share common interests in chromatin biology.

The candidate must have a strong publication record in the broad areas of biology, chemistry, computer science, engineering or physics.

Interested candidates should send a cover letter, CV, and contact info of three references to Lu Gan. Additional details about our group can be found on our website (www.anaphase.org).

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Position

Postdoctoral fellowship / research fellow