Postdoctoral Researcher in HIV related to antiretroviral therapy and cure

Postdoctoral Researcher in HIV related to antiretroviral therapy and cure

Karolinska Institutet (KI)

Huddinge, Sweden

The Department of Medicine, Huddinge, conducts preclinical and clinical research in a variety of areas and undergraduate and graduate education. The department is internationally oriented and consists of seven units with a total of nearly 60 research groups, including three research centres.

The Division of Infectious Diseases conducts preclinical, translational, clinical and epidemiological research projects are conducted. The laboratory is located within the newly build facilities at Alfred Nobels Allé 8 (ANA8), Campus Flemingsberg. This new laboratory, ANA Futura, is creating a leading translational integrated research environment equipped for cutting-edge research, where the boundaries between institutions and clinics are torn down and researchers collaborate on the basis of common research profiles. The announced position will be placed in Professor Anders Sönnerborgs research group, which has a strong focus on pathogenesis, antiretroviral treatment and cure of HIV infection. The experimental research is focused on the interaction between HIV and antiretroviral drugs as well as mechanisms of viral latency.

We are looking for a person with profound knowledge in medical biology with a focus on microbiology, especially virology, but also immunology. Experience of studies on antiviral therapy of chronic viral infections as well as on viruses which cause latent infection is required with focus on pathogenesis, viral replication, resistance development, latency reactivation and on immunology, especially host antiviral immune responses.

The applicant should be able to work with various cell culture systems in order to assess phenotypes and functionality of cells. He/she should have experience in setting up viral assays to evaluate antiviral efficacy, viral fitness and host immune responses and in various cellular and molecular techniques that allow genetic modification of cells ranging from cloning, to transduction experiments.  

Skills in the following techniques are mandatory: i) cell culture systems; both cell lines, primary cells and co-cultures, immune cell isolation from peripheral blood, cellular functionality assays, transfections; ii) flow cytometry analysis; discriminating immune cell subsets, cell surface and intracellular protein stainings, cell death assays; iii) viral assays; lentiviral transductions, virus propagation, viral infectivity experiments; iv) assays of antiviral efficiency; v) other techniques; DNA/RNA isolation from tissues or cells, ELISA, immunofluorescence, immunoprecipitation, luciferase reporter assays, PCR, protein purifications, quantitative PCR, reverse transcriptase, SDS PAGE, western blotting. Knowledge in next generation sequencing and sequence analysis is an extra asset.

Entry requirements
Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence.

Excellent knowledge in English, written and spoken, is a requirement. The work includes writing of human ethical applications.

Bases of assessment
We stress scientific expertise and collaborative skills when assessing applicants.

Personal qualities
The person should be well organized, service-oriented and flexible. A positive and collaborative attitude is a pre-requisite for working in the Sönnerborg group and a great emphasize is put on the collaborative attitude of the applicant. Thus, of importance is that the candidate is well acquainted with collaborative work in a dynamic environment which includes strong social skills.

Application process
An employment application must contain the following documents in English or Swedish:

  1. A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  2. A complete list of publications
  3. A summary of current work (no more than one page)

The application is to be submitted through the Varbi recruitment system.

A post-doc position is a fixed-term position. The first employment is for one year, with a possible extension of up to three years after evaluation.

Karolinska Institutet is one of the world’s leading medical universities. Its vision is to significantly contribute to the improvement of human health. Karolinska Institutet accounts for the single largest share of all academic medical research conducted in Sweden and offers the country’s broadest range of education in medicine and health sciences. The Nobel Assembly at Karolinska Institutet selects the Nobel laureates in Physiology or Medicine.
Pursuant to the regulations of the Swedish National Archives, applications are kept on file for two years after the appointment has gained legal force. The regulations do not apply to attachments that have been printed or otherwise published.
Karolinska Institutet strives to provide a workplace that has approximately the same number of women and men, is free of discrimination and offers equal opportunity to everyone.

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Please apply via recruiter’s website.

Quote Reference: 247619