We are seeking a highly motivated and ambitious individual to join the research group of Eva Hellström Lindberg as a Postdoctoral Fellow to further elucidate stem and progenitor cell dysfunction, molecular pathways underlying pathogenesis and the molecular and cellular mechanisms of ineffective erythropoiesis in myelodysplastic syndromes (MDS). Recent studies from our group on this subject encompass Rydén, et al., Leukemia 2018, Shiozawa, et al., Blood 2017, Mortera Blanco, et al., Blood 2017, Dimitriou, et al., Oncotarget 2016, Conte, et al., Br J Haematology 2015; Malcovati, et al, Blood 2015, Nikpour, et al. Leukemia 2013, Woll, et al., Cancer Cell 2014. We are exploring MDS erythropoiesis along two lines; to understand the competitive advantage of SF3B1 mutated stem cell in the human niche, and to outline the mechanisms behind terminal erythroid failure. The project will take place within the frame of a major collaborative research grant and a large personal grant from the Wallenberg Foundation.
Methods will involve advanced flow cytometry and sorting, DNA and RNA-sequencing, single-cell sequensing, advanced cell culture systems, imaging techniques, and functional analyses of stem and progenitor cells.
The Research group
The research group is based at the Center of Hematology and Regenerative Medicine (HERM), Karolinska Institutet. HERM consists of 16 research groups and approximately 100 people and is a nationally leading and internationally competitive environment for studies of hematopoiesis, blood disorders and the human immune system in the context of malignancy and infectious diseases. The vision is to become one of the leading translational research centers in Europe within this field. The environment offers state-of-the art cell culture, molecular biology, flow cytometry and microscopy facilities. In the http://ki.se/en/medh/eva-hellstrom-lindberg-group, you will be working in an international and interdisciplinary research environment,where collaborative efforts are encouraged.
You are expected to be a talented and enthusiastic researcher with a strong drive to be a part of translational research, be instrumental in the elaboration of scientific hypothesis, experimental design, experimentation, data analysis and presentation/publication of results. You must be a good team player but still retain enough independence to explore your results from a conceptual standpoint. You will be responsible for your own academic, research and administrative activities, adapt existing and develop new scientific techniques, test hypotheses and analyze data from a variety of sources.
Besides studying existing lab projects, postdocs are encouraged to start their own new projects that can serve to launch their independent careers in science. Our aim is to provide a supportive environment for development of independent scientists.
Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.
A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.
A PhD in Cell or Molecular Biology, Hematopoiesis or related sciences is required (2018 or later). Excellent spoken and written English is a requirement. Applicants should have first author publications in recognized peer-reviewed journals.
The position requires experience with some of the above described methodologies but more important is a capacity for scientific thinking, high ambition, and collaborative and communicative skills.
The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.
Type of scholarship
The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.
An employment application must contain the following documents in English or Swedish:
- A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
- A complete list of publications
- A summary of current work (no more than one page)
The application is to be submitted on the Varbi recruitment system.
Karolinska Institutet is one of the world’s leading medical universities. Its vision is to significantly contribute to the improvement of human health. Karolinska Institutet accounts for the single largest share of all academic medical research conducted in Sweden and offers the country’s broadest range of education in medicine and health sciences. The Nobel Assembly at Karolinska Institutet selects the Nobel laureates in Physiology or Medicine.
Pursuant to the regulations of the Swedish National Archives, applications are kept on file for two years after the appointment has gained legal force. The regulations do not apply to attachments that have been printed or otherwise published.
Karolinska Institutet strives to provide a workplace that has approximately the same number of women and men, is free of discrimination and offers equal opportunity to everyone.
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