Scientist I

Scientist I

IDRI

Seattle, WA, United States

The TB Discovery Group
is looking for a Scientist I to work in the drug discovery group. The
successful candidate will be responsible for projects utilizing high content
screens to probe host-pathogen interactions.  The project will utilize
sophisticated high throughput microscopy to identify compounds that potentiate
intracellular bacterial killing, as well as determine mode of action of novel
agents.

 

  • Work under Biosafety Level 3 conditions
    with Mycobacterium tuberculosis
  • Conduct a research and development project
    using high content screens
  • Conduct research to understand mode of
    action of novel anti-mycobacterial compounds
  • Design and implement research plans
  • Troubleshoot and solve experimental and
    technical problems
  • Run a wide range of microbiological and
    cellular assays
  • Writing standard protocols and validation
    data packages
  • Liaising with external collaborators
  • Write manuscripts and assist with grant
    preparation
  • Contribute freely to the team research
    environment in a manner conducive to the success of the research project
    as a whole
  • Establishing and using high throughput
    methods to monitor intracellular replication of mycobacteria and track
    cytotoxicity
  • Genetic manipulation and culture of
    mycobacteria
  • Characterization and selection of
    fluorescent labels for development
  • Developing robust and reproducible high
    content assays using microscopy
  • Implementation of assays to determine key
    pathways and mode of action of compounds
  • Data analysis and parameter selection for
    assays
  • Oversee quality control and data integrity

Qualifications


  • Graduate in relevant biological science

  • PhD in relevant area

  • Minimum of 2 years post-doctoral experience

  • Great lab bench skills, able to maintain
    good lab records and generate scientific hypotheses

  • Good communication skills and able to
    organize and prioritize own work

  • Computer literacy, including word
    processing, Excel and literature searches

  • Scientific publication record with the
    proven ability to effectively write scientific papers

  • Good sense of ethics and the ability to
    maintain confidentiality

  • Able to work effectively with little
    supervision but also a great collaborator

  • Proven record of working well with other
    teams and outside agencies

  • A multi-tasker who is eager to learn new
    skills

  • Able to work at Biosafety level 3

Desirable skills


  • Expertise in
    microscopy

  • Expertise in
    high throughput assay development

  • Expertise in microbial genetics and/or
    cellular assays

  • Experience working with mycobacteria or
    other pathogens

  • Biosafety level 3 (BSL3) experience

 

IDRI offers a comprehensive compensation plan
which includes Medical, Dental, Vision, Life, AD&D and EAP. In addition,
IDRI offers Flexible Spending Accounts, a matching ROTH 401K Retirement Plan
and Commuter benefits.

 

This summary describes a portion of the
essential functions/responsibilities of this position.  It is not an
exhaustive list of all job duties.  Management reserves the right to
modify the duties of this position as necessary.

 

Infectious Disease Research Institute (IDRI)
is an Equal Opportunity Employer. All qualified applicants will receive
consideration for employment without regard to race, color, religion, gender,
gender identity or expression, sexual orientation, national origin, genetics,
disability, age, or veteran status.

 

IDRI is an E-Verify Employer

 

Please apply via recruiter’s website.

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