POST-DOCTORAL & RESEARCH ASSOCIATE POSITIONS:
DEFINING THE ROLE OF HMGA CHROMATIN REMODELING
PROTEINS IN STEM CELLS, AGING, & CANCER BIOLOGY
The laboratory of Dr. Linda Resar is seeking highly motivated and enthusiastic postdoctoral fellows and experienced research associates to join our research team. Our laboratory is currently funded by 4 NIH R01s, Maryland Stem Cell Research Funds, ALSF, and private foundations to study High Mobility Group A epigenetic regulators in cancer, cancer stem cells, normal development, and aging.
The Resar laboratory is located in the Ross Research Building at the Johns Hopkins University School of Medicine in Baltimore, Maryland, with exceptional core facilities, equipment and colleagues.
This position requires a PhD and/or MD in a relevant area with a strong interest in the biology of cancer, stem cells, and/or aging. Innate curiosity, drive, strong work ethic, communication skills, critical thinking, and the ability to work as a team are essential for this position. Previous experience in molecular biology, tissue culture, epigenetics, chromatin architecture, and/or stem cell biology are highly desirable.
Positions currently open include:
1) Biology of intestinal and colon stem cells & gastrointestinal cancer. Candidates should have experience in organoid cultures, RNAseq, and microscopy.
2) HMGA in pediatric leukemia. Candidates preferred with expertise in bioinformatics and knowledge of leukemia.
3) Hematologic malignancy and stem cell biology. Candidates should have experience with bone marrow transplantation using mouse models.
4) Aging biology using mouse and cell-based models. Candidates preferred with experience with mouse models, aging biology, and broad molecular skills.
The Johns Hopkins University School of Medicine
Ross Research Building, Room 1025; 720 Rutland Avenue
Baltimore, MD 21205
Xu Y, Sumter Felder T, Bhattacharya R, Tesfaye A, Wood, LJ, Fuchs E, Huso D, Resar LMS. The HMG-I oncogene causes highly penetrant, metastatic lymphoid malignancy in transgenic mice and is overexpressed in human lymphoid malignancy. Cancer Res 2004;64:3371-5. Published as a Priority Report
Xian L, Georgess D, Huso T, Cope LM, Belton A, Chang Y-T, Kuang W, Gu Q, Zhang X, Senger S, Fasano A, Huso DL, Ewald AJ, Resar LMS. Hmga1 amplifies Wnt Signaling and expands the intestinal stem cell compartment and Paneth cell niche. Nature Commun 2017;8:5008. Cited as paper of significance (Intestinal Cell News; Issue 3.15)
Resar LMS, Chia L, Xian L. Lessons from the crypts: HMGA1 – amping up Wnt for stem cells and tumor progression. Cancer Res 2018;78:1890-97.
Johns Hopkins University School of Medical website: http://www.hopkinsmedicine.org/
Johns Hopkins University website:
All employment decisions shall be consistent with the principle of equal employment opportunity, and only job-related qualifications will be required.