The NeuroGenetics and informatics (NGI) group (https://neurogenomics.wustl.edu/) at Washington University School of Medicine is recruiting multiple Postdoctoral Research Scientist. The NGI generates and analyzes high-throughput multi-dimensional omic data to study neurodegeneration and diseases of the central nervous system with emphasis on Alzheimer’s disease, Parkinson’s disease, and other dementias. The ultimate goal of the NGI is to understand the biology of these diseases, to define novel biomarkers, and to identify novel therapeutical targets. Washington University School of Medicine is renowned for its research cohorts of neurodegenerative disorders, which include clinical, neuroimaging, and fluid biomarker phenotypes. We have pioneered in the employment of whole genome sequencing, genetic analyses of traditional cerebrospinal fluid (CSF) biomarkers and Mendelian Randomization approaches to identify the genetic architecture of neurodegeneration. We are currently employing deep molecular profiling of brain, CSF and plasma, including single-nuclei RNA-seq and proteomics assay, to characterize a large collection of well-characterized samples.
We are seeking for highly motivated researchers at all career stages. We look for post-doc, (senior) staff sceintists and junior faculty with strong analytical skills to join our effort and generate novel insights of neurodegeneration with this unique dataset, while working in a highly dynamic multidisciplinary and collaborative environment. The new scientists will join a large team, currently twenty members, which is led by three faculty members and three senior scientists.
Dr. Cruchaga and Dr. Harari are well funded with several grants from the National Institute of Ageing, the CZI and ongoing collaboration with the pharma industry. Our current research projects include the analyses of:
- GWAS and whole genome sequencing of Neurodegenerative (ND) Cerebrospinal fluid (CSF) biomarkers (Amyloid beta, tau, TREM2, NFL, YKL40 and SNAP25)
- Identification of rare genetic variants in large family-related and unrelated Neurodegenerative sequencing studies
- Plasma, CSF and Brain Proteomic analysis using Mendelian Randomization
- Brain transcriptomic analysis (Bulk RNA-seq/Deconvolution and single-nuclei RNA-seq)
- Liquid biopsy (cell-free DNA/RNA as biomarkers for ND)
- Identification of shared genetic architecture among ND traits (Alzheimer’s, Parkinson and FTD)
For further details please see our website: https://neurogenomics.wustl.edu/
The successful applicant will hold, or shortly expects to obtain, a PhD qualification in Genetics, Bioinformatics, Computer science, Data science, Statistical Genomics or a related discipline involving the interrogation of ‘omics’ datasets. A hands-on experience with large-scale human genomic or other omics (preferably related to neurodegeneration) studies is expected. He/she would have solid skills in at least one programming language (R, python or perl) and experience working in Linux and/or high-performance cluster environments. A strong ability to perform analytical reasoning to extract biological insights from data-driven approaches will be critical. In addition, familiarity to interrogate publicly available resources will be highly beneficial.
We offer competitive salaries and benefits, please refer to the Human Resources website (http://hr.wustl.edu), and Information on being a postdoc at Washington University in St. Louis can be found at http://postdoc.wustl.edu/prospective-postdocs.
Diversity and Inclusion are core values at Washington University. Washington University seeks an exceptionally qualified and diverse faculty, staff, students and postdocs; women, minorities, protected veterans, and candidates with disabilities are strongly encouraged to apply.