Research Associate in Cellular and Molecular Neuroscience (Fixed Term)
Wellcome Trust – MRC Institute of Metabolic Science
We are seeking a postdoctoral applicant to join an interdisciplinary team researching the links between metabolic and neurodegenerative disease. This position in the laboratory of Dr. Florian Merkle (http://www.merklelab.org/) is funded by the Chan Zuckerberg Initiative (CZI, http://go.chanzuckerberg.com/ncn), and will enable the successful applicant to join an international network using innovative approaches to tackle major, unmet challenges in human health.
The position at the University of Cambridge, UK, offers access to world-leading institutions for the study of metabolic disease (http://www.ims.cam.ac.uk/), stem cell biology (https://www.stemcells.cam.ac.uk/), neurodegeneration (https://ukdri.ac.uk/centres/cambridge), and bioinformatics (https://www.sanger.ac.uk/). The research will be performed in part with the aid of local collaborators who are leaders in their fields, including Profs. John Marioni, Giovanna Mallucci, and Sir Stephen O’Rahilly. The position is also unique in that it provides opportunities for structured career development including networking, mentorship, and professional training workshops organized by CZI. This position therefore provides an ideal opportunity for a highly-motivated scientist to advance their career. For more details regarding the project please refer to the Further Particulars.
You will help run a program of research to investigate the molecular and cellular mechanisms that lead to altered neuronal function in disease.
You will be required to:
- Perform molecular biological techniques including RT-qPCR, single-cell RNA sequencing, Western blotting, cloning, and CRISPR/Cas9-based gene editing.
- Perform cellular techniques including human pluripotent stem cell culture, neuronal cell culture, directed differentiation to hypothalamic neurons and other cell type types, and histological analysis of cells and brain tissues including confocal and high-content imaging.
- Present research work and data within the Institute, nationally and internationally and to prepare and submit research for publication in peer-reviewed journals.
- Work effectively as a team member within the lab and collaborate with local and international partners.
To be considered for this position, you must:
- Possess a Ph.D. (or equivalent research doctorate) in neuroscience, molecular or cellular biology, or a closely related field.
- Demonstrate mastery of basic molecular and cellular techniques
- Have a publication record that demonstrates innovation, rigor, and productivity
- Have proven communication skills, as supported by writing and presentation clarity and a track record of conference presentations
- Demonstrate the ability to take leadership of (or participate in) collaborative projects, especially those involving multiple groups
You should have:
- Theoretical training and practical experience in inflammation, neurodegenerative biology, and/or metabolic disease
- Expertise in the culture of human pluripotent stem cells and primary rodent neural cells
- Expertise in bioinformatics and single-cell RNA sequencing
- Expertise in cloning and gene editing
- Expertise in advanced microscopy techniques and high-content imaging
Proposed start date: 6 May 2019 or as soon as possible thereafter
Informal enquiries can be made to Florian Merkle (email@example.com)
Fixed-term: The funds for this post are available for 24 months in the first instance.
To apply online for this vacancy and to view further information about the role, please visit:
Closing date: 07 April 2019 with interviews to be confirmed.
Please ensure that you upload a covering letter and CV in the Upload section of the online application. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
Please quote reference RG18331 on your application and in any correspondence about this vacancy.
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