Advanced Neuro-Imaging & Technologies
Laboratory of Neurotechnology and Biophysics
The Rockefeller University, New York, NY
The emergence of new optical technologies combined with molecular sensors advanced computational tools have led to major advances of our understanding of how the circuitry and dynamics of neuronal population give rise to brain functions and behavior. The Vaziri Lab of Neurotechnology and Biophysics (LNB) has a major focus on the development and application of advanced optical imaging technologies with applications for systems neuroscience. Over the last few years the lab has developed a portfolio of optical techniques that allow near-simultaneous stimulation [1, 2] and functional imaging of neuronal activity on the whole-brain level at single-cell level in small model organisms [3, 4] and more recently in the more scattering rodent brain [5-8].
To further push the boundaries of neurotechnology development and microscopy we are looking for several highly motivated and ambitious candidates at the level of Postdoctoral Associate or (Senior) Research Associate in the in the following areas:
· Development of new high-speed optical methods for large scale recoding of neuroactivity
· Imaging through scattering media
· Computational imaging technologies, machine learning & advanced statistics
· New conceptual applications of quantum optics and ultrafast optics to bioimaging and biology
· Development of early stage technologies for bioimaging and biology based on conceptually new approaches from quantum optics/quantum sensing, ultrafast optics, nano-photonics or acoustics
· Development of new molecular sensors and use of biochemical or synthetic biological approaches
- Highly motivated, ambitious and goal-driven
- PhD in physics, optical / electrical engineering, (quantum) optics, synthetic biology or systems neuroscience
- Demonstrated scientific excellence and substantial contributions in research in candidate’s field
- Prior experimental work on one and more of these areas desired: designing and building optical setups, ultra-fast optics, fiber optics, nano-photonics, acoustics, computational modeling and programming, design of electronic circuits, FPGAs, systems neuroscience, animal surgery or behavior
- Ability to manage multiple tasks and projects and work as part of an interdisciplinary team, excellent organizational and communication skills and willingness to work outside their core expertise.
Interested candidates should send their CV including a list of publications and the contact information of three references to email@example.com For more information please visit our website www.vaziria.com
1. Andrasfalvy, B., et al., Two-photon Single Cell Optogenetic Control of Neuronal Activity by Sculpted Light. PNAS, (2010). 107.
2. Losonczy, A., et al., Network mechanisms of theta related neuronal activity in hippocampal CA1 pyramidal neurons.* Nature Neuroscience*, (2010). 13(8): p. 967-72.
3. Schrodel, T., et al., Brain-wide 3D imaging of neuronal activity in Caenorhabditis elegans with sculpted light. Nature Methods, (2013). 10(10): p. 1013-1020.
4. Prevedel, R., et al., Simultaneous whole-animal 3D imaging of neuronal activity using light-field microscopy. Nature Methods, (2014). 11(7): p. 727-730
5. Robert, R. et al., Fast volumetric calcium imaging across multiple cortical layers using sculpted light. Nature Methods, (2016) 13, 1021-1028
6. Skocek,O., et al., High-speed volumetric imaging of neuronal activity in freely moving rodents. Nature Methods, (2018). 15, 429–432.
7. Nöbauer, T., et al., Video rate volumetric Ca2+ imaging across cortex using seeded iterative demixing (SID) microscopy. Nature Methods, (2017). 14, 811-81.
8. Weisenburger, S. et al., Volumetric Ca2+ Imaging in the Mouse Brain using Hybrid Multiplexed Sculpted Light (HyMS) Microscopy. Cell (2019), in press
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