Three Research Associates: Targeting Post-translational Modification Pathways in Cancer

Three Research Associates: Targeting Post-translational Modification Pathways in Cancer

Imperial College London (ICL)

London, United Kingdom

Job summary

We are seeking three outstanding chemical biologists to lead and collaborate on ongoing drug target discovery and validation projects in the field of cancer, in the group of Professor Ed Tate. The positions are available full time from May 2019, or as soon as possible thereafter, for 36 months in the first instance, and are funded by Cancer Research UK and Worldwide Cancer Research. These roles will involve a high degree of teamwork and multidisciplinary research, and the positions are open to candidates from a range of scientific backgrounds.

Currently undisclosed data obtained in our lab have revealed exciting and previously unappreciated druggable vulnerabilities in post-translational modification pathways in a wide range of currently untreatable cancers, including drug-resistant and metastatic pancreatic, prostate, ovarian and triple-negative breast cancers. Your research will focus on exploring and validating novel drug targets and biomarkers in specific protein lipidation and hydrolytic enzyme pathways, working in sophisticated cell models (patient-derived cell lines, co-culture and 3D culture) and advanced animal models of disease. You will use cutting-edge technologies in chemical probe design, cell-type specific proteomics, analogue-sensitive mutant enzymes, activity-based protein profiling, and system-level bioinformatic analysis, amongst other approaches. You will collaborate extensively with 50 scientists in the Tate group at the state-of-the art £150M Molecular Sciences Research Hub at Imperial’s new White City Campus, and at the Francis Crick Institute in London, and with scientists in industry and internationally.

Duties and responsibilities

• To take initiative in the planning and execution of research, and in the development of collaborations with other groups at Imperial, and with external collaborators
• To direct the work of small research teams, including undergraduate and postgraduate students
• To identify and develop suitable techniques for the collection and analysis of data
• To conduct data analysis
• To ensure the validity and reliability of data at all times
• To maintain accurate and complete records of all findings

Essential requirements

• A PhD in a molecular science (for example, chemical biology, molecular biology, biochemistry, medicinal chemistry, etc.), or an equivalent level of professional qualifications and experience
• A strong research track record, preferably evidenced by significant publications or patents
• Independent capability and creativity in hypothesis generation and experimental design
• Ability to set and attain research objectives as part of a multidisciplinary team
• Ability to mentor and develop junior team members

Training can be provided in all required techniques, but prior experience in one of the following areas is essential:

• Multidisciplinary chemical biology, chemical probe design and/or applications in disease models
• Cancer cell biology and hypothesis-driven drug target validation/analysis in cancer
• Chemical proteomics and/or chemical genetics for drug target discovery and validation
• Protein biochemistry and molecular biology

Hands-on experience with cell culture and phenotypic/pathway analysis (e.g. microscopy, cytometry, RNA-seq analysis) is desirable.

Further information

*Candidates who have not yet been officially awarded their PhD will be appointed as Research Assistant within the salary range £34,397 – £37,486 per annum.

For informal enquiries about the post, please contact Professor Ed Tate: e.tate@imperial.ac.uk 
(http://www.imperial.ac.uk/tate-group/). 

If you have any queries, please contact Nayrin Noori, Senior HR Administrator: n.noori@imperial.ac.uk. For technical queries during the application process, please contact recruitment@imperial.ac.uk 


The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/ 

Committed to equality and valuing diversity. Imperial College is also an Athena SWAN Silver Award winner, a Stonewall Diversity Champion, a Disability Confident Employer and is working in partnership with GIRES to promote respect for trans people.

About Imperial College London

Imperial College London is the UK’s only university focussed entirely on science, engineering, medicine and business and we are consistently rated in the top 10 universities in the world.

You will find our main London campus in South Kensington, with our hospital campuses located nearby in West and North London. We also have Silwood Park in Berkshire and state-of-the-art facilities in development at our major new campus in White City.

We work in a multidisciplinary and diverse community for education, research, translation and commercialisation, harnessing science and innovation to tackle the big global challenges our complex world faces.

It’s our mission to achieve enduring excellence in all that we do for the benefit of society – and we are looking for the most talented people to help us get there.

Additional information

Please note that job descriptions cannot be exhaustive and the post-holder may be required to undertake other duties, which are broadly in line with the above key responsibilities.

All Imperial employees are expected to follow the 7 principles of Imperial Expectations: 

  • Champion a positive approach to change and opportunity
  • Communicate regularly and effectively within, and across, teams
  • Consider the thoughts and expectations of others
  • Deliver positive outcomes
  • Encourage inclusive participation and eliminate discrimination
  • Develop and grow skills and expertise
  • Work in a planned and managed way 

In addition to the above, employees are required to observe and comply with all College policies and regulations.

Imperial College is committed to equality of opportunity, to eliminating discrimination and to creating an inclusive working environment. We are an Athena SWAN Silver award winner, a Stonewall Diversity Champion, a Disability Confident Employer and work in partnership with GIRES to promote respect for trans people.

Please apply via recruiter’s website.

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