Postdoctoral Scientist - Molecular Cell Biology

NDM Experimental Medicine, University of Oxford

Oxford, South East England, United Kingdom

Salary: Grade 7: £32,236 - £39,609 p.a.

We are seeking a postdoctoral researcher to work as part of Richard Wheeler’s group which focuses on the molecular cell biology of Leishmania mexicana and Trypanosoma brucei. These are both important human parasites which are highly motile active swimmers, driven by a single flagellum. The current research focus is a Wellcome Trust-funded research project to determine how the molecular motors which drive flagellum beating are regulated to generate the necessary flagellum beat for different swimming behaviours, with the ultimate aim of determining roles of cell motility in pathogenicity.

This role will be based at Peter Medawar Building for Pathogen Research, South Parks Road, Oxford.

The post will involve extensive light microscopy, electron microscopy, cell and molecular biology and image analysis. Particular opportunities include CRISPR/Cas9-assisted engineering of the parasite genome, development of new approaches for visualising the live beating flagellum by high speed light microscopy and cryo-electron tomography to determine the molecular conformation of motor proteins within the flagellum axoneme. Experience in these techniques would be a distinct advantage, however previous experience is not essential and full training will be provided.

You will have a first degree in a biological sciences and Laboratory experience in cell and/or molecular biology.

This role will be offered as full-time and fixed-term, for 3 years in the first instance.

Applications for this vacancy are to be made online. You will be required to upload a supporting statement and CV as part of your online application.

Only applications received before 12.00 midday on 29 March 2019 will be considered.

Please apply via recruiter’s website.

Quote Reference: University of Oxford-itox_ac-139457