Postdoctoral Position in Synthetic Biology
A postdoctoral research position is available immediately for a highly
motivated and creative scientist to join our Laboratory of Synthetic Biology at
the National Institute for Biotechnology. The successful candidate will join a
dynamic team in an ERC-funded interdisciplinary research at the interface of
synthetic biology, chemical biology and biochemistry.
Synthetic biology is an emerging discipline that offers powerful tools to
control and manipulate fundamental processes in living matter. The Arbely lab
develops and applies such tools to modify the genetic code of cultured
mammalian cells and bacteria with the aim of studying the role of lysine acylation
(e.g., acetylation) in the regulation of metabolism and in cancer development.
Thousands of lysine acetylation sites were recently discovered on non-histone
proteins, suggesting that acetylation is a widespread and evolutionarily conserved
post-translational modification. Specifically, it has been found that most of
the enzymes of metabolic processes, including glycolysis, are acetylated,
implying that acetylation is a key regulator of cellular metabolism in general
and glycolysis in particular. The aim of this project is to understand the role
of acetylation in the regulation of glycolysis and in the metabolic
reprogramming of cancer cells. Our experimental approach is based on the use of
genetic code expansion technology to genetically encode the incorporation of
The position is suited for enthusiastic and passionate applicants with a
strong background in cell biology and chemical biology work. The ideal
candidate will have ample experience in mammalian cell culture. In addition,
experience in some of the following fields/techniques would be an advantage: molecular
cloning, biochemical assays of metabolic enzymes, qRT-PCR,
cell imaging, immunohistochemistry, protein expression (in bacteria) and
purification, and directed evolution. Prior experience or background in
synthetic organic chemistry or directed evolution may also be an advantage.
While the research will focus on the use of genetic code expansion technology
in cultured mammalian cells, candidates with experience in yeast culture work
are encouraged to apply.
For more information, please visit our website: https://eyalrb.wixsite.com/arbelylab
. Applications should include (in a single PDF file): (i) a cover letter
specifying relevant qualifications, training, and research interests (ii)
curriculum vitae with potential referees, (iii) one peer-reviewed publication.
Please send your application to Dr. Eyal Arbely, firstname.lastname@example.org .