Salary: Grade 6: £28,660 - £34,189 p.a.
N-glycosylation is one of the most common forms of post-translational modifications that is essential to all eukaryotic life. However, we know little about the function of most N-linked glycans, or how the process is regulated. It was recently discovered that patients suffering from Congenital Myasthenic Syndromes had genetic variants in genes involved in N-glycosylation. These patients suffer mostly from muscle weakness caused by abnormalities in the development and function of their neuromuscular junctions.
This post is funded by the MRC to work with Dr Yin Yao Dong to study enzymes in the N-glycosylation pathway, and why mutations in these enzymes lead to abnormalities in the neuromuscular junction.
The successful candidate will gain exposure to a variety of different scientific techniques in molecular and cellular biology, biochemistry and structural biology. They will also be collaborating with molecular and cellular biologists from Professor David Beesons group and structural biologists from Prof Liz Carpenters group at the Structural Genomics Consortium (SGC).
This post is based in the Weatherall Institute of Molecular Medicine (WIMM), but will require regular trips to the Old Road Campus to use the biophysics and crystallography facilities at the SGC.
The post is full-time and fixed-term until 31 January 2024 in the first instance.
Only applications received before 12.00 midday on 18 March 2019 will be considered. Interviews will be held as soon as possible thereafter.