Postdoctoral Position – Structural Biologist/Biochemist – DNA Repair
The Caglayan lab in the Department of Biochemistry and Molecular Biology, University of Florida seek an outstanding individual with Ph.D. training in biochemistry and/or structural biology to study the DNA repair.
The NIH-funded research project will focus on studying genome stability and oxidative stress-induced DNA damage processing. For more information, please see the lab website at https://caglayan.biochem.med.ufl.edu
Duties will include:
Supporting projects through original research, collaboration with other team members, interpreting and critically evaluating primary literature; collection and analysis of data; and maintaining a complete, accurate, and up-to-date lab notebook; preparing and editing manuscripts for publication as well as applications for grants; attending an annual meeting to disseminate research findings and progress; supervising and training of graduate students (PhD and Master’s level) and undergraduates. Applicants should have excellent communication and problem-solving skills and the ability to work flexible hours depending on specific experiments.
The Caglayan group is in both the Department of Biochemistry and Molecular Biology, and UF Health Cancer Center with investigators renowned for their contributions to the area of biochemistry and cancer biology. This exceptional training environment offers a highly supportive and collaborative scientific experience in many diverse areas of expertise.
1) Caglayan M. and Wilson S.H. Pol μ dGTP mismatch insertion opposite T coupled with ligation reveals a promutagenic DNA intermediate during double strand break repair. Nature Communications (2018) 9: 4213.
2) Caglayan M., Prasad R., Krasich R., Longley M.J., Kadoda K., Tsuda M., Sasanuma H., Takeda S., Tano K., Copeland W.C., Wilson S.H. Complementation of aprataxin deficiency by base excision repair enzymes in mitochondrial extracts. Nucleic Acids Research (2017) 17: 10079 – 10088.
3) Caglayan M., Wilson S.H. Role of DNA polymerase β oxidized nucleotide insertion in DNA ligation failure. Journal of Radiation Research (2017) 1093: 1 – 5.
4) Caglayan M., Horton J.K., Da-Peng D., Stefanick D.F., Wilson S.H. Oxidized nucleotide insertion by pol β confounds ligation during base excision repair. Nature Communications (2017) 8: 14045.
5) Caglayan M., Wilson S.H. Oxidant and environmental toxicant-induced effects compromise DNA ligation during base excision DNA repair. DNA Repair (2015) 35: 85 – 89.
6) Caglayan M., Horton J.K., Prasad R., Wilson S.H. Complementation of aprataxin deficiency by base excision repair enzymes. Nucleic Acids Research (2015) 43: 2271 – 2281.
7) Caglayan M., Batra V.K., Sassa A., Prasad R., Wilson S.H. Role of polymerase β in complementing aprataxin deficiency during abasic-site base excision repair. Nature Structural and Molecular Biology (2014) 21: 497 – 499.
PhD, MD, or PhD/MD degree in a related discipline.
The candidate should have experience in biochemistry, enzymology, and structural biology. Previous working experience with evidence of experimental skills related to X-ray crystallography and/or Cryo-EM with DNA repair proteins is preferred.
The salary for this position is commensurate with experience as determined by NIH guidelines.
Special Instructions to Applicants:
All applicants must also apply through the Careers at UF posting https://apply.interfolio.com/59230.