We are seeking a highly motivated postdoctoral fellow to join the laboratory of Dr. Advaitha Madireddy (www.madireddylab.com) in the Division of Pediatric Hematology/Oncology at the Rutgers Cancer Institute of New Jersey and the Robert Wood Johnson Medical School. The research in our laboratory focuses on investigating novel molecular mechanisms and oncogenic pathways that underlie the pathogenesis of cancer-predisposition syndromes and hematological malignancies. In particular, we are exploring the contribution of defective replication, transcription and repair to genomic instability in disorders like Fanconi anemia (FA) (Madireddy et al., 2017; Madireddy et al., 2016) and Adult T-cell leukemia/lymphoma. In addition to our studies on determining the molecular basis of cancer-predisposition, we are also interested in understanding the primary mechanisms underlying hematopoietic stem cell exhaustion/attrition and bone marrow failure using a human stem cell model for FA. Additional broad areas of research emphasis include: Non-B DNA at genomic hotspots of fragility, helicases/translesion polymerases/nucleases, and transcription: replication conflicts.
Our team is integrated into the Genomic Instabilities and Cancer Genetics Program at our NCI-designated Cancer Institute. This opportunity is ideal for postdocs who are interested in basic cancer research.
o PhD in molecular biology, cell Biology, biochemistry or related area. Recent PhD graduates and candidates with prior postdoctoral experience who are committed to a dynamic career in science are encouraged to apply.
o Able to design research projects, perform hands on experiments, and maintain detailed documentation.
o Highly motivated, creative, and devoted to project and career goals.
o Able to collaborate proficiently and communicate effectively with colleagues.
o A strong background in molecular, cell and(or) cancer biology is essential.
o Hands-on experience with general molecular biology techniques and in vitro assays commonly used to study DNA replication, transcription, and DNA repair preferred.
o Prior experience in at least one of the following techniques is strongly desired: Human stem cell culture (hematopoietic stem cell culture), ChIP-seq analysis, Crispr/Cas9 genome editing.
To apply, please email a cover letter, CV, and the names and contact information (including phone numbers) of three references to Advaitha.firstname.lastname@example.org. In addition, please submit an online application through the following website: https://jobs.rutgers.edu/postings/84525