We welcome postdoctoral applicants who are interested in applying pluripotent stem cell models to address basic mechanistic questions in the development, function and disease of human nervous system. Applicants with expertise in genomics, differentiation of pluripotent stem cells, or neural development/neuroscience are of particular interest at this time. Applicants that obtain their doctoral degree within 1-2 years are preferred.
The Yang laboratory at the Black Family Stem Cell Institute and Department of Neuroscience of Icahn School of Medicine at Mount Sinai seeks to understand how the nervous system achieves its extraordinary cellular and functional complexity and how neuropsychiatric disorder associated genetic variants affect its composition and function. To study these questions, we use stem cells to generate different types of cells in the brain including neuronal and glial cells to reconstitute human nervous system in a dish and elucidate the underlying signaling interactions, cellular information processing, and gene expression regulation that govern basic activities of cells and coordinates all cell actions. Currently, we are particularly interested in making progresses in understanding how disease associated risk variants in non-coding regions contribute to pathogenesis of multiple neuropsychiatric disorders including autism spectrum disorder, bipolar disorder and schizophrenia.