Three Postdoctoral Positions in Medicinal Chemistry and Drug Discovery

Three Postdoctoral Positions in Medicinal Chemistry and Drug Discovery

Istanbul Medipol University

Istanbul, Turkey

Three (3) Postdoctoral Positions in Medicinal Chemistry and Drug Discovery

Prof. Mustafa Guzel (Guzel Research Group) at Istanbul Medipol University in Turkey, Prof. Morten Grøtli (Grøtli lab) at University of Gothenburg and Prof. Adil Mardinoglu (Mardinoglu Lab) at KTH-Royal Institute of Technology in Sweden have announced a joint collaboration research project to develop novel drug candidates for the treatment of non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D). We are seeking for highly motivated three postdoctoral researchers in Medicinal Chemistry with a strong publication record. The candidates must be self-motivated and able to work independently but also to work efficiently in an international team setting. The project will be carried out in the lab of Guzel Research Group at Istanbul Medipol University REMER (Regenerative and Restorative Medicine Research Center) (https://remer.medipol.edu.tr/) in Istanbul, Turkey.

The Guzel Research Group (http://grg.medipol.edu.tr/) mainly focus on drug discovery and development of various therapeutic targets such as Neurodegenerative Disorders (ALS, Alzheimer’s and Parkinson’s disease etc.), and Inflammatory Disorders (COPD, RA), GPCRs for the treatment of Diabetic Disorders (NIDDM), Cancer, Cardiovascular Disorders, Obesity, and other Metabolic Disorders. Guzel Research Group is also interested in research and development with an emphasis in design and synthesis of both symmetric and asymmetric organic drug-like molecules leading to new drug substances and natural products as well as the discovery of drugs to treat unmet medical needs in the world.

The Grøtli lab (http://grotlilab.net/) focus on the use of synthetic organic chemistry to produce novel compounds for the study of complex cellular pathways in cell biology and medicine. Such compounds are interesting both as potential therapeutics and as experimental tools for understanding the physiological roles of the target proteins. Two types of compounds are of special interest: probes for visualization (e.g. fluorescence-based sensors for detection of enzymatic activity in vivo and in vitro; fluorescent-nucleic acid base analogues), and probes for selective perturbation of biological processes (e.g. kinase inhibitors).

The Mardinoglu Lab (http://sysmedicine.com/) at at SciLifeLab, Stockholm, Sweden develop Genome-scale metabolic models (GEMs) and Integrated biological networks for human cells/tissues and employ these comprehensive models in the analysis of the omics data obtained from subjects with complex diseases including non-alcoholic fatty liver disease (NAFLD), type 2 diabetes (T2D) and certain types of cancer. This is an exciting area of biomedical research, driven by the increase of common metabolic disorders as well as recent discoveries of metabolic reprogramming in cancer.

Three postdoctoral researchers in Medicinal Chemistry
The targets (PKLR and PKM) kinases has been identified by the Mardinoglu group using Systems Biology and the successful candidates will develop PKL/PKR/PKM activators targeting these kinases. Candidates will develop multistep synthesis of lead compounds in order to study structure-activity relationships, with guidance from computer-based drug design and biological testing. The project will be carried out at the Drug Discovery and Development Lab of Regenerative and Restorative Medicine Research (REMER) Center of Istanbul Medipol University, under daily supervision of Prof. Mustafa Guzel as well as the Prof. Morten Grøtli and Prof. Adil Mardinoglu via weekly and bi-weekly meetings. The project will provide an opportunity to practice cutting edge medicinal chemistry in an interdisciplinary context that directly impacts the discovery of new therapeutics for global unmet medical needs.

Qualifications:
• The ideal candidate must hold a PhD or equivalent doctoral degree in synthetic organic chemistry, medicinal chemistry and/or chemical biology with a proven track-record of success as demonstrated by publications in high-impact, peer-reviewed journals. Teamwork and strong communication skills are essential.
• Applicants must demonstrate a strong background in synthetic organic chemistry, medicinal chemistry.

• Applicants should possess strong desire to develop novel therapeutics.
• Applicants should demonstrate a strong publication record reflecting knowledge of and interest in synthesis of bioactive compounds.

• Applicants should be able to deliver required tasks on a timely manner to achieve the goal of the project.

Written application should directly be sent via e-mail to the Prof. Mustafa Guzel (mguzel@medipol.edu.tr).

Written application must include the following:
1. CV
2. Personal letter stating the reasons why the study suits the applicant (maximum one page)
3. List of publications including citation index (e.g. Google scholar)
4. Contact information for three references

Application deadline: March, 31, 20019
Start date: According to agreement, as soon as possible is desirable
Scholarship period: The scholarship covers a period of 12 months with possibility of prolongation for another 12 months.

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Three Postdoctoral Positions in Medicinal Chemistry and Drug Discovery