Postdoc scholarship in Non-Visual Photoreception

Postdoc scholarship in Non-Visual Photoreception

Umeå Centre for Molecular Medicine (UCMM), Umeå University

Umeå, Sweden

A Postdoctoral Scholarship is available in the laboratory of Prof. Lena Gunhaga at the University of Umeå, Sweden. The project will be conducted in collaboration with Prof. Richard Lang at the Visual Systems Group and Center for Chronobiology, Cincinnati Children’s Hospital, United States. We are seeking highly motivated applicants for a position in the fields of light receptors, circadian biology and nervous system development. The ideal candidate is expected to work both independently and as part of an interactive team.

The full-time scholarship is for 1+1 year (the possibility a renewal for at least one year, pending satisfactory performance). Starting date: As soon as possible.

Project description
Most adult mammalian tissues synchronize their circadian clocks to the daily cycles of light and darkness. However, little is known about how light response pathways affect embryonic development, but several examples have emerged including the regulation of neural and vascular development (Rao et al., Nature, 2013, 494:243-6). This complements previous knowledge regarding how external signalling molecules, including time of exposure to signals, have been shown to regulate the development of the nervous system (Sjödal et al, Dev. Cell, 2007, 13, 141-149, Pandit et al., Development, 2015, 142, 1850-1859; Palaniappan et al., 2018, 145, 153791). The main focus of this project is to understand the molecular mechanisms that control light- and opsin-dependent development of the nervous system.

The applicant will investigate how non-visual opsin signaling affects embryonic development. The applicant will perform functional assessments of light response pathways in the chick and mouse. Methods would include transcriptome analysis, chick in ovo electroporations, mouse genetic analysis and tissue culture. The study would also require common developmental and molecular biology methods such as cloning of expression constructs, immunohistochemistry, in situ hybridization, and also statistical analyses and image analysis.

Qualifications
The ideal candidate should have a PhD in genetics, molecular or developmental biology (or similar). A thorough theoretical and practical grounding in molecular and cell biology is a prerequisite, and knowledge within the fields of the circadian clock and light-receptors is an advantage. Practical experience with model systems for the study of vertebrate embryogenesis, molecular and cell biology methods and photic entrainment is an advantage. The applicant should be proficient in written and spoken English, and have good computer skills (Word, Photoshop, Excel). Of importance are also the candidate’s independence as well as their organizational and problem-solving skills.

Application
To apply for this position, please submit a PDF (max 4 pages) containing:
1) a letter of interest describing relevant experience and research interest,
2) curriculum vitae including methods that the applicant master,
3) names and e-mail addresses for two or more references, with stated professional relationship with the applicant.

Please submit the PDF to lena.gunhaga@umu.se to be received asap.

We look forward to receiving your application!

Information about us
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Postdoc scholarship in Non-Visual Photoreception