UPMC Hillman Cancer Center
Affiliated with University of Pittsburgh School of Medicine
Postdoctoral positions are available to pursue an NCI funded project on DNA damage signaling in the Stewart-Ornstein Laboratory. In the recently established Stewart-Ornstein Laboratory in Department of Computational and Systems Biology at the University of Pittsburgh we seek to understand how DNA damage signaling is tuned across tissues in our body and modified in cancers for the purposes of developing improved and more precisely targeted therapies. Our lab is based at the Hillman Cancer Center and embedded within a very strong genome stability group at the University of Pittsburgh, which ranks fifth in NIH funding nationally.
The Stewart-Ornstein laboratory uses both wet and dry lab approaches and expertise is welcomed in either, though the ideal candidate would have interest in both aspects of research. We use live cell imaging, single cell approaches, genetic screens (cas9ko, cas9i), genomic tools (NGS assays of RNA, ChIP, Chromatin structure), and mathematical models to study the variation in DNA damage signaling and to understand how this signaling might be manipulated to improve cancer therapy. Projects will initially focus on how non-genetic cellular states alter the DNA damage response and promote persistence after chemotherapy and radiation treatment. Linkages between DNA damage signaling and oncogenic and immune signaling pathways are also areas of interest.
-PhD in molecular, systems, or computational biology or similar.
-Capable of independent and collaborative work, strong writing and presentation skills
-Significant publication record
Interested candidates please forward your curriculum vitae and names of three references to Dr. Jacob Stewart-Ornstein (JAS632@pitt.edu).
The University of Pittsburgh offers a comprehensive salary program and excellent benefits in a smoke and drug free workplace. The University of Pittsburgh School of Medicine is an Affirmative Action/Equal Opportunity Employer and encourages applications from under-represented groups. EEO / AA/ M /F Vets / Disabled.
Jacob Stewart-Ornstein, PhD
Dept. Computational and Systems Biology
U. Pittsburgh & Hillman Cancer Center