We seek a postdoctoral fellow with strong mass spectrometry skills to develop new methods for exposomics in human biofluids that will be integrated into studies of human health and development. This will involve multiplexing of target methods for trace-contaminants in limited volumes of sample, and development of new workflows in nontarget mass spectrometry (GC- and LC-Orbitrap) to characterize complex environmental chemical mixtures in human serum or urine. The position is a two year postdoctoral fellowship fully funded by the Swedish Research Council, Formas. You will work in a larger team of toxicologists, molecular biologists and epidemiologists on a project at SciLifeLab with the overall goal to determine if paternal exposure to mixtures of environmental contaminants may affect offspring via epigenetic inheritance. To this end, we have recently initiated a unique birth cohort in Sweden to test hypotheses about environmental exposures (exposome) and subsequent human development, health and disease.
The postdoctoral fellow will be supervised by Professors Jonathan Martin and Oskar Karlsson in the Exposure & Effects Unit, Department of ACES. The successful candidate will work primarily at Science for Life Laboratory (SciLifeLab) in the Ultratrace NonTarget Lab (UNTarget) where a major objective will be to establish analytical conditions, sample preparation, and data analysis workflows for comprehensive small molecule profiling and quantification in biofluids using HPLC- or GC-Orbitrap instruments. A combination of targeted analysis, suspect-screening and untargeted workflows are to be established. The candidate will need to develop sensitive methods with excellent quality control, interpret high resolution mass spectrometry data, conduct MS/MS experiments, and quantify or semi-quantify analytes in complex biofluid samples. The postdoctoral fellow will be expected to plan, conduct, interpret and communicate the research and results.
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