Multiple postdoctoral positions are available to study the role that genetic and environmental factors play in increasing the risk of neurodegenerative diseases, particularly Alzheimer’s disease (AD). Our work focuses on the early dysfunction of the endosomal-exosomal pathways that predispose neurons to AD pathobiology, studied in mouse models and cell culture systems. NIA funded positions are available immediately working in areas that include the mechanisms of apolipoprotein E4-mediated endosomal-exosomal pathway disruption, the role of diet in modulating neuronal endosomal function, and the molecular mechanisms by which diabetes can contribute to AD risk.
These projects are collaborative, involving multiple laboratories within the Nathan S. Kline Institute (NKI) (recent publications include: Peng et al., Brain, 2018; East et al., Neuroscience, 2018; Nuriel et al., Front Neurosci., 2017; Peng et al., Neuroscience, 2017) that have a shared interest in understanding the cell biological responses to different apolipoprotein E alleles and to diabetes that predispose neurons to neurodegenerative risk both early in AD as well as independently of hallmark AD pathology (Drs. Mathews, Levy, and Wilson). Our studies use multidisciplinary approaches including behavioral and electrophysiological (single-unit ensemble and local field potential) testing of mouse models, morphological analyses using immunolabeling and confocal microscopy, protein biochemistry, genomic (RNA-seq), proteomic and lipidomic approaches applied to mouse brain tissue, human postmortem brain tissue, and in vitro cultured cells. Therapeutic strategies building upon the protective effects of apolipoprotein E2 are one of the long-term goals of our studies. We are examining small molecules that protectively modulate the endosomal-exosomal pathway in translational models. Additionally, our newly funded diabetes work will examine kinase modulation as a therapeutic mechanism to mitigate AD risk in the diabetic patient.
The laboratories are located within the Center for Dementia Research at the Nathan S. Kline Institute (NKI), which is a consortium of investigators who are dedicated to studies on the pathogenesis, diagnosis, and treatment of AD and other major neurodegenerative diseases. The institute is in Orangeburg, NY close to New York City, and provides a unique research and training opportunity in a multidisciplinary setting. The NKI is affiliated with New York University School of Medicine, and a shuttle runs daily between NYU and the NKI. Joint laboratory meetings, seminar series, shared resources including mouse colonies, and a collaborative environment contribute to a strong training environment.
Please visit Dr. Mathews’ Lab website for information on his lab members, research and publications:
Dr. Levy’s at https://www.nki.rfmh.org/research/center-dementia-research-cdr/levy-lab;
Dr. Wilson’s at https://www.nki.rfmh.org/research/emotional-brain-institute-ebi/wilson-lab
Useful prior experience includes:
• familiarity with standard rodent behavioral assessments
• mouse surgery
• cell culture, primary neuronal cultures
• tissue and cell immunolabeling for confocal microscopy, live cell imaging
• PCR, Western blot
• in vivo electrophysiology
Applicants must have a recent Ph.D. or the equivalent. Applicants with an academic and research background in cell biology and/or electrophysiology will be given priority. In addition to these criteria, the successful applicant will have a strong record of written productivity, including prior manuscripts and, potentially, fellowship applications. Appropriate grant and fellowship applications will be strongly encouraged by the successful candidate.
To apply, please send a full CV, a brief statement of current research and long-term goal, and names and contact information of three references to Dr. Mathews at Paul.Mathews@nki.rfmh.org. The CVs of compelling candidates will be shared among the PIs involved in these collaborative studies.
An Excellent Benefits Package is available through the Research Foundation for Mental Health (RFMH), which administers grant support at the NKI. Affirmative Action/Equal Opportunity Employer/Minority/Women/Disabled/Veteran Employer. VEVRAA 41 CFR 60-300.5(a) compliant.
Applications are accepted through the RFMH website at: http://corporate.rfmh.org – Click on Employment Opportunities. Applications through RFMH will be accepted during the posting dates as listed at the top of the job announcement.
Questions regarding this position please email: email@example.com