Sr Research Scientist I
We are seeking an exceptional scientist to join the Fibrosis Biology group at Gilead to focus on metabolic and lipid alterations that contribute to NASH pathogenesis. This position offers a unique opportunity to drive research efforts to discover and develop novel therapies for the treatment of NASH and other chronic metabolic and fibrotic diseases. This individual will support and lead discovery, drug development and translational research efforts aimed at identifying and characterizing novel therapeutic targets and advancing discovery research projects through to clinical development.
Gilead Sciences is a world leader in antiviral research having developed small molecule compounds that have revolutionized the treatment of HIV, HCV, and HBV. Over the last 5 years, Gilead has significantly broadened its scope to encompass unmet medical needs in chronic fibrotic diseases including non-alcoholic steatohepatitis (NASH) and diabetic kidney disease (DKD). Gilead has developed a pipeline of investigational compounds which are currently in late-stage clinical trials for NASH. Our research team is intensively engaged in the discovery and development of additional small molecule and antibody therapeutics and combination therapies for patients with early and advanced liver fibrosis. This position provides an exciting opportunity to have high-impact participation in the growth of these new therapeutic areas within an established research group focused on developing drugs for fibrotic diseases.
Essential Duties and Job Responsibilities:
The successful candidate will work in a project team-based research structure to lead or support biological investigations of new and established projects within Research. The candidate will be expected to significantly participate in and lead discovery efforts for fibrosis targets including defining and implementing critical path studies needed to support hypothesis-based research and will manage these activities in our group across multiple project teams. The candidate will also be involved in initiating and managing new and established external collaborations. The successful candidate will participate as an engaged member of a highly interactive biology department.
Knowledge, Experience and Skills:
Applicants must have a PhD or equivalent degree and at least 3+ years of relevant post-doctoral experience and 3+ years of experience in pharmaceutical industry setting. The candidate will have a strong track record of scientific accomplishments, demonstrated by peer-reviewed scientific publications in high impact journals. Preference will be given to candidates with direct expertise in identifying and validating molecular targets that contribute to the pathophysiology of metabolic dysfunction (obesity, diabetes, dyslipidemia), NAFLD/NASH or related disorders. This should include an understanding of molecular pathways that contribute to metabolic syndrome, hepatocyte lipid metabolism, inflammation and liver fibrosis and in applying cell-based assays to interrogate drug targets and therapeutics in relevant cell types including hepatocytes, myofibroblasts and immune cells. The candidate should be fluent in the use of molecular techniques to evaluate signaling networks (western blot, ELISA, proteomics), gene expression analysis (RT-PCR, Nanostring, RNA-seq), and will have a working knowledge of functional genomics and pathway analysis. The ideal candidate will have experience applying data from human transcriptomics and genomic databases to enable target discovery and validation. Familiarity with the design and execution of in vivo pharmacology studies with relevant preclinical models is a plus.
This individual will have demonstrable skills and experience in hypothesis-driven biological research. Strong communication skills are required, with an ability to communicate and scientifically engage individuals across a large breadth of levels and translate ideas and data into concise written and verbal communications.
To apply, visit http://apptrkr.com/1389799
As an equal opportunity employer, Gilead Sciences Inc. is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans’ Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact email@example.com for assistance.