PhD scholarship in Biomaterials-based Approach for Stem Cells Differentiation

PhD scholarship in Biomaterials-based Approach for Stem Cells Differentiation

Technical University of Denmark (DTU)

2800 Kgs. Lyngby, Denmark

Are you interested in the interplay between regenerative medicine and materials science?

A 3-year PhD position is available at the Biomimetics, Biocarriers and Bioimplants group (The 3Bs) headed by Assoc. Prof. Leticia Hosta-Rigau, DTU Health Tech, Technical University of Denmark, Kgs. Lyngby, Denmark.

The 3Bs is a highly interdisciplinary and positive group with open-minded and supportive members. The 3Bs research lies on the interface of materials science, organic/polymer chemistry together with molecular and cell biology. The research focus areas of the group are drug delivery, tissue engineering and cell mimicry.

The 3Bs are well embedded into the Biopharma division, where multiple young research groups work closely together to create a motivating environment.

Within this announced position, we will develop a biomaterials-based approach to direct the differentiation of stem cells (ASCs and iPSCs) towards various/different tissue-specific cells.

The position is available as soon as possible.

Responsibilities and tasks
Stem cells are able to differentiate into any cell type of the human body and, as such, hold tremendous potential in tissue engineering, cell-replacement therapy and drug screening. However, current differentiation procedures mainly rely on the use of growth factors and/or feeder cells, resulting in heterogeneous cell types, lack of repeatability, immune rejection and contamination.

Since it is now widely accepted that biophysical cues (i.e., topography or matrix-elasticity) play an equally important role in governing cell’s fate, engineered biomaterials have emerged as a powerful tool to direct stem cell’s fate avoiding (or at least minimizing) the use of the less-safe biochemical factors.

The successful candidate will work in a highly interdisciplinary project in the interface of materials science together with molecular and stem cell biology.

The research project will be focused in the fabrication of a fine-tuned substrate to direct stem cells fate towards tissue-specific cells.

The successful candidate will be responsible of:

  • Engineering and assembling cell substrates with defined topography and deformability
  • Conduct a thorough characterization of the as-prepared substrate by means of several techniques
  • Assess the potential of the different substrates in promoting stem cells differentiation into various/different cell lineages
  • Stem and tissue-specific cell characterization


Qualifications
Candidates should have a two-year master's degree (120 ECTS points) or a similar degree with an academic level equivalent to a two-year master's degree.

Preference will be given to candidates that:

  • Have hands on experience in stem cells (ASCs and iPSCs) maintenance and differentiation
  • Have experience with molecular biology techniques (PCR, qRT-PCR, DNA/RNA and protein purification procedures, western blotting)
  • Have experience with several of the following techniques: FACS, immunohistochemistry, live-cell imaging, imaging using confocal microscopy, histology.


You must also be highly independent, driven, and be able to speak and write English fluently.

Approval and Enrolment
The scholarship for the PhD degree is subject to academic approval, and the candidate will be enrolled in one of the general degree programmes at DTU. For information about our enrolment requirements and the general planning of the PhD study programme, please see the DTU PhD Guide.

Assessment
The assessment of the applicants will be made by Associate Professor Leticia Hosta-Rigau.

We offer
DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility.

Salary and appointment terms
The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union. The period of employment is 3 years.

You can read more about career paths at DTU here.

Further information
Further information may be obtained from Associate Professor Leticia Hosta-Rigau, leri@dtu.dk

You can read more about DTU Health Tech on www.healthtech.dtu.dk

Application
Please submit your online application no later than 7 March 2019 (local time).

Apply online at www.career.dtu.dk.

To apply, please open the link "Apply online", fill out the online application form. The following must be attached in English:

  • A letter motivating the application (cover letter)
  • Curriculum vitae
  • Grade transcripts and BSc/MSc diploma
  • Excel sheet with translation of grades to the Danish grading system (see guidelines and Excel spreadsheet here)


Candidates may apply prior to ob­tai­ning their master's degree but cannot begin before having received it.

Applications and enclosures received after the deadline will not be considered.

All interested candidates irrespective of age, gender, race, disability, religion or ethnic background are encouraged to apply.

The DTU Health Technology Department located at the so-called “Medicon Valley”, is an international-class research platform where around 300 researchers work together to provide new technology and new solutions to improve the quality of patient care and public health and well-being

DTU is a technical university providing internationally leading research, education, innovation and scientific advice. Our staff of 6,000 advance science and technology to create innovative solutions that meet the demands of society, and our 11,200 students are being educated to address the technological challenges of the future. DTU is an independent academic university collaborating globally with business, industry, government and public agencies.

Please apply via recruiter’s website.

Quote Reference: Technical University of Denmark-technical_uni_of_denmark-51935

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