Postdoctoral Scientist – Kinase Inhibitor Development

Structural Genomics Consortium, University of Oxford

Oxford, South East England, United Kingdom

Salary: Grade 7: Salary in the range £32,236 - £35,211 p.a.

We are seeking a highly enthusiastic and dedicated Postdoctoral Research Scientist to work on development of an in vivo compatible inhibitor of LIMK1 for treating Fragile X syndrome in Dr Jon Elkins’ group at the Structural Genomics Consortium (SGC). You will be involved in a large collaborative project funded by the Medical Research Council and involving groups in Cardiff, Dundee and Oxford.

You will be joining a group of experienced structural biologists and biochemists with a background in developing specific inhibitors of challenging enzymes. You will be responsible for producing proteins and solving structures by X-ray crystallography. In addition you will be involved in biophysical and biochemical characterisation of the binding of the inhibitors to LIMK1. You will help to guide the development and improvement of the inhibitors. You will have the opportunity to learn new skills, be involved in a large collaboration, publish high quality papers and be involved in cutting edge science focused on curing human disease.

To qualify for this post you would need to hold a PhD in a relevant area of protein science and biochemistry, either awarded, submitted for final thesis or close to submission. You should have proven experience in protein expression and purification. The ideal candidate will also have experience in one of protein crystallography or biophysical or biochemical characterisation of enzyme inhibitors, but this is not essential. You will have excellent presentation and written communication skills, and have a proven record in preparation of high quality research publications. You will be highly self-motivated, well-organised and flexible, with strong planning and problem solving skills, able to work independently and as part of a team, and to collaborate with colleagues and external collaborators.

This is a fixed-term contract up until 31 January 2021

Only applications received before 12.00 noon on Monday 11 March 2019 will be considered.

Please apply via recruiter’s website.

Quote Reference: University of Oxford-itox_ac-138948