Postdoctoral Fellow – Single Cell Genomics
Salary range: £31,897-£39,986 per annum depending on experience plus excellent benefits.
Fixed Term Contract for 3 Years.
Applications are invited for a 3-year Postdoctoral Fellowship within the Genomics of Inflammation and Immunity group at the Wellcome Sanger Institute (WSI), headed by Dr. Carl Anderson (www.andersonlab.info). Our group uses large-scale genetic and genomic data to understand the biological basis of inflammatory bowel disease (IBD) risk and progression. The ultimate goal of our IBD research is to identify new drug targets for the disease, and ascertain which individuals should be prescribed a given drug.
The project will generate single-cell transcriptomic data from intestinal biopsies obtained from 300 healthy individuals undergoing colonoscopy. All individuals will also be genotyped, with the goal of combining these datasets to map eQTLs across the more than forty different cell-types in the gut. The results from these analyses will then be combined with our detailed maps of IBD risk loci (and other gastrointestinal diseases) to identify genes that are dysregulated to bring about disease. The ultimate goal of the research is thus to improve our basic knowledge of IBD pathogenesis and identify novel candidate drug targets for treating disease.
This project forms part of the Open Targets collaboration (www.opentargets.org/), a public-private initiative between the Wellcome Sanger Institute (WSI), EMBL-EBI, GlaxoSmithKline (GSK), Biogen, Celgene, Takeda and Sanofi to combine large-scale genomic experiments with statistical and computational methods to identify and validate the causal links between targets, pathways and diseases. As a postdoctoral fellow working on this project, you will also benefit from close interactions with collaborating scientists from Open Targets pharmaceutical partners.
Based at the WSI, you will use your established expertise in single-cell genomics and/or QTL mapping to lead the analysis and ensure that the project delivers on its ambitious goals. You will take intellectual ownership of the project and think broadly about questions that can be addressed using the data. You will collaborate closely with other members of the Anderson Lab working on a similar project to build a single-cell derived map of gut eQTLs from biopsies ascertained from Crohn’s disease patients with active inflammation. As such, this project will suit a self-motivated individual with good communication skills who is looking to make a personal contribution to genomic research at the interface of academia and the pharmaceutical industry.
• Ability to work with others in a collegiate and collaborative environment.
• Motivation and ambition to make a personal contribution to genomic research
• A PhD in a relevant subject (genetics, functional genomics, computer science, maths)
• Experience with large-scale computational analysis
• Statistical/computational genetics skills and an analytical mindset
• Previous experience with analysis of genotype, sequence or functional genomic data
• Experience with computer programming & scripting
• An attention to detail and a drive for rigor
• A strong scientific publication record
• An interest in understanding the biological basis of immune-mediated diseases
Open Targets is a pioneering public-private initiative between GlaxoSmithKline (GSK), Biogen, Takeda, Celgene, Sanofi, EMBL-EBI (European Bioinformatics Institute) and the WSI (Wellcome Sanger Institute), located on the Wellcome Genome Campus in Hinxton, near Cambridge, UK.
Open Targets aims to generate evidence on the biological validity of therapeutic targets and provide an initial assessment of the likely effectiveness of pharmacological intervention on these targets, using genome-scale experiments and analysis. Open Targets aims to provide an R&D framework that applies to all aspects of human disease, to improve the success rate for discovering new medicines and share its data openly in the interests of accelerating drug discovery.
Our Campus: Set over 125 acres, the stunning and dynamic Wellcome Genome Campus is the biggest aggregate concentration of people in the world working on the common theme of Genomes and BioData. It brings together a diverse and exceptional scientific community, committed to delivering life-changing science with the reach, scale and imagination to pursue some of humanity’s greatest challenges.
Our Benefits: Our employees have access to a comprehensive range of benefits and facilities including:
• Group Defined Contribution Pension Scheme and Life Assurance
• Group Income Protection
• Private Health Insurance
• 25 days annual leave, increasing by one day a year to a maximum of 30
• Family friendly environment including options for flexible and part-time working, a childcare voucher scheme and Campus Nursery
• Two days paid Employee Volunteering Leave a year
• Employee Discount Scheme
• Campus Gym, tennis courts, cricket pitch and sports hall plus a range of dining facilities
• Active Campus Sports and Social Club
• Free Campus Bus Service
Genome Research Limited hold an Athena SWAN Bronze Award and will consider all individuals without discrimination and are committed to creating an inclusive environment for all employees, where everyone can thrive.
Please include a covering letter and CV with your application.
Closing date: 18th March 2019, however applications will be reviewed on an ongoing basis and therefore the post may be filled before the deadline.