Research Assistant / Associate (drug discovery)

Research Assistant / Associate (drug discovery)

Wren Therapeutics Limited

Cambridge, United Kingdom

Job title: Research Assistant / Associate (drug discovery)

Location: Central Cambridge

Salary range: Competitive salary. Eligible for company-wide discretionary annual bonus plan.

Job summary: Wren Therapeutics Limited is seeking to appoint a talented research assistant or associate for its rapidly growing research division. The appointee will assist in running a busy experimental laboratory and will have specific responsibility, amongst other duties, for the expression, purification and characterisation of recombinant peptides and proteins, including amyloid forming proteins. The appointee will also conduct drug discovery research projects, together with other members of the team, and will contribute to the development and application of new methodologies.

• Assist in running a busy experimental laboratory, including maintaining bacterial strains, designing experiments, and carrying-out both molecular and biochemical assays.
• Take a lead role in protein production and purification, including recombinantly expressing and purifying misfolding-related proteins and peptides.
• Write or contribute to publications or disseminate research findings using other media, including making presentations at conferences or exhibiting work at academic or industry conferences.
• Communicate complex ideas and concepts to those with limited knowledge and understanding as well as to peers.
• Mentor and coach colleagues with less experience.

Skills, qualifications and experience needed:
• Undergraduate degree in chemistry, biochemistry, molecular biology or a related discipline, at a leading academic institution.
• Specific research expertise in the topic of protein misfolding and aggregation. In particular, experience working experimentally with amyloid forming proteins is highly preferred.
• Extensive experience in the recombinant expression (in bacteria or yeast systems) and purification of misfolding-related and amyloid forming proteins and peptides, using a variety of chromatography techniques (e.g. Akta purification systems, HPLC) and characterisation of their purity using optical spectroscopy, SDS-PAGE analysis and western blotting.
• Experience in site-directed mutagenesis, molecular cloning and other related techniques is beneficial.
• Experience in assisting to run a busy biophysical, biochemical or molecular biology laboratory (i.e. purchasing, maintenance of equipment related to protein purification, DNA/protein stock organisation).
• Fluency in English.

Closing date for applications: Applications must be received by 31st March 2019

Application procedure: Please send a cover letter and CV to

About Wren Therapeutics (Wren): Wren ( is a spin-off company from the University of Cambridge (UK) and Lund University (Sweden), focused on drug discovery and development for protein misfolding diseases. Wren is advancing an entirely novel approach to address this class of diseases, based on more than a decade of research from its scientific founders focused on the chemical kinetics of the protein misfolding process. These advances make it possible to map, and selectively modulate, the complex and non-linear chemical kinetic networks associated with misfolding proteins and disease. Wren’s predictive, quantitative platform is built on concepts from the physical sciences and is a fundamental shift from the descriptive, qualitative methods of traditional biology, which have failed to successfully address these complex systems. Wren is using its unique approach to develop a broad pipeline of small molecule and antibody therapeutics, as well as diagnostics, spanning neurology, ophthalmology and metabolic diseases.


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Research Assistant / Associate (drug discovery)