Funded post-doctoral positions are available in the Shen laboratory to investigate the molecular mechanisms of genitourinary development and tumorigenesis. We are a dynamic, highly-collaborative group that investigates research topics at the interface of developmental, stem cell, and cancer biology (https://www.genetics.cumc.columbia.edu/research-labs/shen-lab). We are seeking highly-motivated applicants with a commitment to excellence for studies in the following areas:
1) Prostate organogenesis, stem/progenitor cells, and lineage specification – we use lineage-tracing and single-cell approaches to understand development, regeneration, and repair of the normal prostate. (Wang et al. (2009) Nature 461: 495-500 PMID: 19741607; Toivanenet al. (2016) Stem Cell Rep. 6: 660-667 PMID: 27117783; Toivanen and Shen (2017) Development 144: 1382-1398 PMID 28400434; Talos et al. (2017) Nat. Comm. 8: 14662 PMID:28429718)
2) Prostate cancer initiation, progression, and castration-resistance – we use genetically-engineered mouse models and organoid culture approaches to elucidate cell types of origin as well as molecular mechanisms of prostate tumorigenesis (Wang et al. (2013) Nat. Cell Biol. 15: 274-283 PMID: 23434823; Wang et al. (2014)Cell Rep. 8: 1339-1346 PMID: 25176651; Chua et al.(2014) Nat. Cell Biol.16: 951-961 PMID 25241035; Lee and Shen (2015) Curr. Opin. Cell Biol. 23: 35-41 PMID: 26506127; Zou et al. (2017) Cancer Discov. 7: 736-749 PMID 28400434; Chua et al. (2018)eLife 7: e28768 PMID: 29334357)
3) Molecular mechanisms of bladder cancer – we use human patient-derived organoid and xenograft models to analyze clonal evolution, drug response, and metastasis in bladder cancer (Lee et al. (2018) Cell 173: 515-528 PMID: 29625057)
Successful candidates will have a Ph.D. degree with a strong background in stem cell biology, developmental biology, and/or cancer research. Expertise with mouse models, organoid culture, imaging, single-cell sequencing, genomic analyses, and/or bioinformatics would be advantageous.
To apply, please send a CV, detailed description of research experience and future interests, and the names of three references.
Columbia University is an Equal Opportunity/Affirmative Action employer.