Mass Spectrometry Computational Scientist

Mass Spectrometry Computational Scientist

Harvard Medical School/Brigham and Women's Hospital

Boston, MA, United States

The Center for Interdisciplinary Cardiovascular Sciences (CICS; Director: Masanori Aikawa, MD, PhD) at the Brigham and Women’s Hospital (BWH), a Harvard-affiliated hospital, is seeking a postdoctoral research fellow to contribute to its bioinformatics program within the Proteomics Research Group (Director: Sasha Singh, PhD).

 

We are seeking individuals to collaborate with biologists on three major endeavors: 1) Analysis of high dimensional data acquired from a multi-omics study that includes one or more of proteomics, metabolomics and transcriptomics for drug target discovery. 2) Posttranslational modification mapping and characterization. 3) Expanding on current targeted proteomics workflows and implementation of spectral libraries into peptide identification workflows.

Additional projects that would interest the candidate include single-cell transcript profiling, and systems biology and artificial intelligence-driven studies aimed to predict the beneficial and off-target effects of putative therapeutics. The successful candidate will be able to collaborate with a number of talented researchers, will guide them through their research endeavors and will be a co-author on publications arising from these projects.

 

Specific requirements: The candidate must have a PhD or equivalent experience. The candidate will help to expand a bioinformatics program for mass spectrometry-based target discovery platforms.  Specific skill requirements include data analysis with statistics, script languages such as Python, programming languages such as C, C++, C# or JAVA, and scripting in Linux/UNIX. Experience with computational mass spectrometry analysis is preferred; however, basic knowledge of mass spectrometry or equivalent biochemistry will also be considered.  Experience in systems biology and/or machine learning is also advantageous. We also expect an individual with outstanding motivation and a firm commitment to productivity. 

 

About us.

We launched CICS in collaboration with Kowa Company Ltd, a Japanese pharmaceutical company. This academia-industry collaboration ­­develops and utilizes state-of-the-art platforms that in part rely on mass spectrometry-based strategies for drug target discovery research. We conduct interdisciplinary, team-driven research with scientists from BWH and Kowa working together in a shared space. Our intent is to establish a diverse, active and innovative working environment. We thus seek a highly motivated candidate with excellent interpersonal skills. CICS occupies a fully-equipped 25,000-sq.ft. space on the 17th floor of the Center for Life Sciences in the Longwood Medical Area, the heart of Boston’s medical and research community. The Proteomics team has integrated into the CICS program the most current technologies available for qualitative and quantitative bottom-up mass spectrometry using high resolution and high accuracy instrument platforms. Our research scope includes global proteome profiling using label-free and isobaric tandem mass tagging methods. We also apply a variety of quantitative mass spectrometry strategies and mathematical modeling approaches for stable isotope labeling in the clinic. In addition, we have recently implemented a metabolomics platform at the center.

 

Please visit our website at http://cics.bwh.harvard.edu for further information about CICS.

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Mass Spectrometry Computational Scientist