Research Assistant - Antigen Delivery

University of Oxford

Oxford, South East England, United Kingdom

Salary: Grade 6: £28,660 - £34,189 p.a.

The Department of Oncology within the Oxford University’s Medical Sciences Division serves to enhance the coordination of clinical and basic cancer research in Oxford. The Department is the second largest in Medical Sciences Division. Its activities currently cover four sites: The Old Road Campus Research Building; the Weatherall Institute of Molecular Medicine at the John Radcliffe Hospital; the Radiobiology Research Institute on the Churchill Hospital site; clinical services and facilities at the Cancer Hospital.

Research in Dr Jiang’s laboratory focuses on understanding mechanisms of antigen presentation to the immune system; biomarker discovery and the development of new vaccines, including therapeutic vaccines with a particular emphasis on translating discoveries into new treatments for cancer patients. One major outcome of this work has been the development of a recombinant overlapping peptides technology for cancer therapeutic vaccines and diagnostics. This innovation led to the formation of a spinout company, which is progressing two candidates to clinical trials. Meanwhile the lab continues to focus on reaching an in-depth understanding of the immune pathways activated by the technology and identifying additional targets that are amenable to the approach.

A research assistant will be recruited for a year for a project supported by Innovate UK to develop a mucosal vaccine combining ROP and vector-based technology.

Working as part of a group and reporting to the Principal Investigator (Dr Shisong Jiang), the postholder will provide research support for a project to evaluate a novel route of antigen delivery using engineered recombinant overlapping peptides. The appointee will gain a thorough understanding of the project in order to help design experiments, prepare samples, carry out assays and analyse, summarise and present data. They provide advice and guidance to research students where appropriate.

The successful candidate will hold a first degree, together with some relevant experience and will also be working toward a doctorate in a specialist discipline. They will need to be experienced in maintaining mammalian cells including cell lines and primary cells. Familiarity with using fluorescent and confocal microscopy, along with proficiency in the establishment and use of immunoassays (ELISA, ELISPOT) are also essential requirements for this role.

This is a full-time post, fixed-term for 12 months.

All applicants must complete an application form and will be required to upload a CV and supporting statement.

The closing date for applications is 12.00 noon on Wednesday 6 March 2019.

Please apply via recruiter’s website.

Quote Reference: University of Oxford-itox_ac-139254