Postdoctoral Scientist in Structural and Stem Cell Biology

Nuffield Division of Clinical Laboratory Sciences, University of Oxford

Oxford, South East England, United Kingdom

Salary: Grade 7: £32,236 - £39,609 p.a.


This is a unique opportunity for a driven, highly motivated and talented Postdoctoral Scientist to join the research group of Professor Catherine Porcher to characterise and solve the structure of a multiprotein complex involved in the transcriptional regulation of blood stem cell development in normal and malignant conditions.

This exciting project, at the forefront of its field, is a collaboration with Dr Denis Ptchelkine leading structural biology research at the MRC Weatherall Institute of Molecular Medicine. It will employ molecular, biochemical, biophysical and cryo-EM studies. Key residues involved in protein/protein and protein/DNA interactions will be identified and functionally analysed. This high impact study will provide essential details for a mechanistic understanding of the transcriptional activities of this blood stem cell-specific complex.

The position is available fixed-term for 24 months, funded by the Medical Research Council (MRC).

You will hold a PhD (or near to completion: thesis submitted) in a relevant area, with experience in molecular biology, cloning strategies, tissue culture, protein expression and purification and biochemical and biophysical assays. You will have excellent communication and organisational skills, with the ability to work as part of a team as well as to manage and independently drive your own research. Previous experience in cryo-EM is desirable.

Applications for this vacancy are to be made online. You will be required to upload a CV and supporting statement as part of your online application.

The closing date for this position is 12.00 noon on Friday 1 March 2019.

Please apply via recruiter’s website.

Quote Reference: University of Oxford-itox_ac-139214