Institute Associate Scientist II - Drug Metabolism and Pharmacokinetics Research Group
MD Anderson Cancer Center
Houston, TX, United States
Posted about 3 days agoExpires on April 19, 2019
MD Anderson is known for providing cancer patients with exceptional care, which includes early access to innovative new treatments through clinical trials. The Institute for Applied Cancer Science (IACS) is a new hybrid model that uniquely combines the drug discovery capabilities of the biopharmaceutical industry and the extensive knowledge of biology found in academia with the expertise of MD Anderson's top clinicians. IACS has the singular goal of rapidly developing novel, effective and safe therapeutics that improve patient health. IACS executes programs with the highest probability of clinical success in a rigorous, goal-oriented, data-driven manner.
We are seeking a highly motivated and team-oriented individual to join our ADME/PK group to support our fast-paced drug discovery programs. The Institute Associate Scientist II will use LC-MS to characterize or quantitate in vitro and in vivo biological samples of small molecule drug candidate compounds. Ideal candidate will have solid chemistry background and /or LC-MS instrument experience obtained from an internship or work experience in addition to required education.
1. Under minimal supervision, process plasma, tumor and any other tissue samples using liquid handling automation systems or solid phase extraction (SPE) for liquid chromatography mass spectrometry (LC-MS) analysis.
2. Conduct in vitro ADME incubation assays such as plasma stability assay, microsomal stability assay, hepatocyte incubation, and plasma-protein binding assay.
3. Conduct LC-MS/MS method development of new small molecule drug candidate compounds.
4. Use LC-MS for sample analysis, data acquisition, data analysis, and generate final bioanalytical reports.
6. Conduct routine LC-MS instrument maintenance and performance check.
7. Employ safe lab practices.
8. Maintain research records and laboratory notes.
9. Participate in integrated drug discovery research project teams.
Required: Bachelor's degree in Biology, Biochemistry, Molecular Biology, Cell Biology, Enzymology, Pharmacology, Chemistry or related field.
Preferred: Master's degree in Medicinal Chemistry, Organic Chemistry, Biochemistry, Pharmacology, Chemistry, Biology or related field.
Required: Eighteen months of relevant research laboratory experience. With preferred degree, no required experience.
Preferred: 2 years' experience in Medicinal Chemistry, Organic Chemistry, Enzymology, Analytical Chemistry, Cell Culture or Pharmacology. Capable of doing routine instrument (LC-MS) maintenance.
It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html
Employee Status: Regular
Minimum Salary: US Dollar (USD) 48,000
Midpoint Salary: US Dollar (USD) 67,000
Maximum Salary : US Dollar (USD) 86,000